Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations

Michael W. Jann, Chang Wen-Ho, Y. W.Francis Lam, Hai G. Hwu, Lin Hsin-Nan, Chen Horng, Teng Y. Chen, Lin Shih-Ku, Chien Ching-Piao, Chester M. Davis, Larry Ereshefsky, Stephen R. Saklad, Ann L. Richards, William M. Scholteis

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

1. 1. Plasma haloperidol and reduced haloperidol concentration were measured in four ethnic populations. 2. 2. Plasma samples were obtained under steady-state conditions and obtained 10-12 hours post bedtime dose and prior to the morning dose. 3. 3. Haloperidol and reduced haloperidol plasma levels were assayed by radioimmunoassay and liquid chromatography. 4. 4. A wide interpatient variability between haloperidol dose and plasma concentration was observed for each ethnic group. 5. 5. The Chinese group differed from the other ethnic populations. 6. 6. A nonlinear relationship was observed between haloperidol and reduced haloperidol plasma levels in each ethnic group. Further, the relationship of haloperidol to reduced haloperidol plasma levels differed for each ethnic group. These results suggest that various ethnic groups could metabolize haloperidol and reduced haloperidol differently.

Original languageEnglish (US)
Pages (from-to)193-202
Number of pages10
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume16
Issue number2
DOIs
StatePublished - Mar 1992

Keywords

  • ethnicity
  • haloperidol
  • reduced haloperidol

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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    Jann, M. W., Wen-Ho, C., Lam, Y. W. F., Hwu, H. G., Hsin-Nan, L., Horng, C., Chen, T. Y., Shih-Ku, L., Ching-Piao, C., Davis, C. M., Ereshefsky, L., Saklad, S. R., Richards, A. L., & Scholteis, W. M. (1992). Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations. Progress in Neuropsychopharmacology and Biological Psychiatry, 16(2), 193-202. https://doi.org/10.1016/0278-5846(92)90070-U