Comparison of changes in tryptophan and serotonin in regions of the hamster and the rat brain over a twenty-four hour period

William W. Morgan; Karla A. Pfeil; Russel J. Reiter; Elpidia Gonzales

doi:10.1016/0006-8993(76)90557-6

Comparison of changes in tryptophan and serotonin in regions of the hamster and the rat brain over a twenty-four hour period

William W. Morgan, Karla A. Pfeil, Russel J. Reiter, Elpidia Gonzales

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

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Abstract

Groups of male golden hamsters and Sprague-Dawley rats were sacrificed at 4-h intervals over a 24-h period. Tryptophan and serotonin (5-HT) were measured in the telencephalon and brain stem and tryptophan was measured in serum. Highly statistically significant changes in tryptophan and 5-HT content were observed over the period of the day. Generally the changes were more clearly defined and were significant to a higher statistical level in the hamster than in the rat. Statistically significant changes were also observed in serum tryptophan. In the hamster the daily changes in serum tryptophan were coincidental with similar changes in tryptophan and 5-HT in the brain stem and tryptophan in the telencephalon. On the other hand, the changes in 5-HT in the hamster telencephalon were not well correlated with changes in tryptophan and serum tryptophan.

Original language	English (US)
Pages (from-to)	77-84
Number of pages	8
Journal	Brain Research
Volume	117
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(76)90557-6
State	Published - Nov 19 1976

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(76)90557-6

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title = "Comparison of changes in tryptophan and serotonin in regions of the hamster and the rat brain over a twenty-four hour period",

abstract = "Groups of male golden hamsters and Sprague-Dawley rats were sacrificed at 4-h intervals over a 24-h period. Tryptophan and serotonin (5-HT) were measured in the telencephalon and brain stem and tryptophan was measured in serum. Highly statistically significant changes in tryptophan and 5-HT content were observed over the period of the day. Generally the changes were more clearly defined and were significant to a higher statistical level in the hamster than in the rat. Statistically significant changes were also observed in serum tryptophan. In the hamster the daily changes in serum tryptophan were coincidental with similar changes in tryptophan and 5-HT in the brain stem and tryptophan in the telencephalon. On the other hand, the changes in 5-HT in the hamster telencephalon were not well correlated with changes in tryptophan and serum tryptophan.",

author = "Morgan, {William W.} and Pfeil, {Karla A.} and Reiter, {Russel J.} and Elpidia Gonzales",

note = "Funding Information: This study was supported by NASA Grant NSG 9012 to W.W.M.; NSF Grant BMS 74-06275 A01 to R.J.R.; and W.W.M. is the recipient of N.I.H. Research Scientist Development Award l K02 MH00028-01.",

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doi = "10.1016/0006-8993(76)90557-6",

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T1 - Comparison of changes in tryptophan and serotonin in regions of the hamster and the rat brain over a twenty-four hour period

AU - Morgan, William W.

AU - Pfeil, Karla A.

AU - Reiter, Russel J.

AU - Gonzales, Elpidia

N1 - Funding Information: This study was supported by NASA Grant NSG 9012 to W.W.M.; NSF Grant BMS 74-06275 A01 to R.J.R.; and W.W.M. is the recipient of N.I.H. Research Scientist Development Award l K02 MH00028-01.

PY - 1976/11/19

Y1 - 1976/11/19

N2 - Groups of male golden hamsters and Sprague-Dawley rats were sacrificed at 4-h intervals over a 24-h period. Tryptophan and serotonin (5-HT) were measured in the telencephalon and brain stem and tryptophan was measured in serum. Highly statistically significant changes in tryptophan and 5-HT content were observed over the period of the day. Generally the changes were more clearly defined and were significant to a higher statistical level in the hamster than in the rat. Statistically significant changes were also observed in serum tryptophan. In the hamster the daily changes in serum tryptophan were coincidental with similar changes in tryptophan and 5-HT in the brain stem and tryptophan in the telencephalon. On the other hand, the changes in 5-HT in the hamster telencephalon were not well correlated with changes in tryptophan and serum tryptophan.

AB - Groups of male golden hamsters and Sprague-Dawley rats were sacrificed at 4-h intervals over a 24-h period. Tryptophan and serotonin (5-HT) were measured in the telencephalon and brain stem and tryptophan was measured in serum. Highly statistically significant changes in tryptophan and 5-HT content were observed over the period of the day. Generally the changes were more clearly defined and were significant to a higher statistical level in the hamster than in the rat. Statistically significant changes were also observed in serum tryptophan. In the hamster the daily changes in serum tryptophan were coincidental with similar changes in tryptophan and 5-HT in the brain stem and tryptophan in the telencephalon. On the other hand, the changes in 5-HT in the hamster telencephalon were not well correlated with changes in tryptophan and serum tryptophan.

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Comparison of changes in tryptophan and serotonin in regions of the hamster and the rat brain over a twenty-four hour period

Abstract

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