Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic models of invasive candidiasis

Nathan Wiederhold, L. K. Najvar, R. Bocanegra, W. R. Kirkpatrick, Thomas F Patterson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We compared the rate and extent of anidulafungin's and fluconazole's activity in neutropenic and non-neutropenic mice with Candida albicans invasive candidiasis. In immunocompetent mice, anidulafungin significantly improved survival vs. controls and fluconazole, and significant reductions in (1→3)-β-D-glucan and fungal burden were observed. In neutropenic animals, the highest doses of anidulafungin (5mg/kg) and fluconazole (10mg/kg) also improved survival and reduced fungal burden. However, there were no differences in survival between these antifungals as anidulafungin's activity was attenuated in this model. These results demonstrate that the extent of anidulafungin in vivo efficacy may be dependent on host immune status.

Original languageEnglish (US)
JournalClinical Microbiology and Infection
Volume18
Issue number2
DOIs
StatePublished - Feb 2012

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anidulafungin
Invasive Candidiasis
Fluconazole
Candida albicans

Keywords

  • Anidulafungin
  • Candida albicans
  • Candidiasis
  • Fluconazole
  • Neutropenia

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic models of invasive candidiasis. / Wiederhold, Nathan; Najvar, L. K.; Bocanegra, R.; Kirkpatrick, W. R.; Patterson, Thomas F.

In: Clinical Microbiology and Infection, Vol. 18, No. 2, 02.2012.

Research output: Contribution to journalArticle

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