Comparative value of 99mTc-sestamibi scintimammography and sonography in the diagnostic workup of breast masses

Anita J. Klaus, William C. Klingensmith, Steve H. Parker, A. Thomas Stavros, Jerome D. Sutherland, Kathy D. Aldrete

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


OBJECTIVE. This study was conducted to assess the relative roles of 99mTc-sestamibi scintimammography and sonography in the evaluation of breast lesions that are indeterminate or suspicious on mammography or clinical examination. SUBJECTS AND METHODS. Twenty-five patients with 33 biopsy-proven breast lesions underwent both scintimamography and sonography. Lesions were categorized as benign or requiting biopsy on the basis of the absence or presence of a focus of increased activity on scintimammography and the shape, orientation, and echogenicity of the lesion on sonography. RESULTS. Sensitivity and specificity in detecting breast cancer were 92% and 95%, respectively, for scintimammography and 100% and 48%, respectively, for sonography. The higher specificity of scintimammography was statistically significant (p<0.01). CONCLUSION. Although the overall accuracy of 99mTc- sestamibi scintimammography in the diagnosis of breast cancer was high, it has several disadvantages in comparison with sonography Scintimammography has a slightly higher false-negative rate for breast cancer, is unable to reveal cysts, is more expensive, takes longer to perform, and involves ionizing radiation. For these reasons, scintimammography with 99mTc-sestamibi is unlikely to either replace sonography or be frequently used in addition to sonography.

Original languageEnglish (US)
Pages (from-to)1779-1783
Number of pages5
JournalAmerican Journal of Roentgenology
Issue number6
StatePublished - Jun 2000
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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