Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1073-1076 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 40 |
| Issue number | 4 |
| State | Published - 1980 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin. / Iyer, R. P.; Lyga, J. W.; Secrist, J. A.; Daub, G. H.; Slaga, Thomas J.
In: Cancer Research, Vol. 40, No. 4, 1980, p. 1073-1076.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin
AU - Iyer, R. P.
AU - Lyga, J. W.
AU - Secrist, J. A.
AU - Daub, G. H.
AU - Slaga, Thomas J
PY - 1980
Y1 - 1980
N2 - The abilities of various mono and dimethyl derivatives of benzo(a)pyrene (BP) to initiate skin tumors in mice were determined by using a 2-stage system of tumorigenesis. 11-Methylbenzo(a)pyrene was found to be approximately 3 times more active as a tumor initiator than was the parent hydrocarbon; 1-methyl benzo(a)pyrene was about twice as active as was BP. Substitution of a methyl group in positions 7, 8, 9, or 10 of BP, which would be involved in a bay-region diol-epoxide, completely counteracts the tumor-initiating ability of BP. 3-, 4-, and 12-methyl-benzo(a)pyrenes had activity equivalent to that of BP, whereas 2-, 5-, and 6-methylbenzo(a)pyrenes, as well as 1.2-, 4.5-, 1.6-, and 3.6-dimethylbenzo(a)pyrenes, were all less active than BP. The concepts of steric inhibition of metabolic activation and stereospecific activation are suggested to explain the tumor-initiating activities of various methylated derivatives.
AB - The abilities of various mono and dimethyl derivatives of benzo(a)pyrene (BP) to initiate skin tumors in mice were determined by using a 2-stage system of tumorigenesis. 11-Methylbenzo(a)pyrene was found to be approximately 3 times more active as a tumor initiator than was the parent hydrocarbon; 1-methyl benzo(a)pyrene was about twice as active as was BP. Substitution of a methyl group in positions 7, 8, 9, or 10 of BP, which would be involved in a bay-region diol-epoxide, completely counteracts the tumor-initiating ability of BP. 3-, 4-, and 12-methyl-benzo(a)pyrenes had activity equivalent to that of BP, whereas 2-, 5-, and 6-methylbenzo(a)pyrenes, as well as 1.2-, 4.5-, 1.6-, and 3.6-dimethylbenzo(a)pyrenes, were all less active than BP. The concepts of steric inhibition of metabolic activation and stereospecific activation are suggested to explain the tumor-initiating activities of various methylated derivatives.
UR - http://www.scopus.com/inward/record.url?scp=0018898532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018898532&partnerID=8YFLogxK
M3 - Article
C2 - 7357537
AN - SCOPUS:0018898532
VL - 40
SP - 1073
EP - 1076
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 4
ER -