Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin

R. P. Iyer, J. W. Lyga, J. A. Secrist, G. H. Daub, Thomas J Slaga

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)1073-1076
Number of pages4
JournalCancer Research
Volume40
Issue number4
StatePublished - 1980
Externally publishedYes

Fingerprint

Benzo(a)pyrene
Skin
Pyrenes
Neoplasms
Epoxy Compounds
Hydrocarbons
Carcinogens
Carcinogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Iyer, R. P., Lyga, J. W., Secrist, J. A., Daub, G. H., & Slaga, T. J. (1980). Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin. Cancer Research, 40(4), 1073-1076.

Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin. / Iyer, R. P.; Lyga, J. W.; Secrist, J. A.; Daub, G. H.; Slaga, Thomas J.

In: Cancer Research, Vol. 40, No. 4, 1980, p. 1073-1076.

Research output: Contribution to journalArticle

Iyer, RP, Lyga, JW, Secrist, JA, Daub, GH & Slaga, TJ 1980, 'Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin', Cancer Research, vol. 40, no. 4, pp. 1073-1076.
Iyer, R. P. ; Lyga, J. W. ; Secrist, J. A. ; Daub, G. H. ; Slaga, Thomas J. / Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin. In: Cancer Research. 1980 ; Vol. 40, No. 4. pp. 1073-1076.
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abstract = "The abilities of various mono and dimethyl derivatives of benzo(a)pyrene (BP) to initiate skin tumors in mice were determined by using a 2-stage system of tumorigenesis. 11-Methylbenzo(a)pyrene was found to be approximately 3 times more active as a tumor initiator than was the parent hydrocarbon; 1-methyl benzo(a)pyrene was about twice as active as was BP. Substitution of a methyl group in positions 7, 8, 9, or 10 of BP, which would be involved in a bay-region diol-epoxide, completely counteracts the tumor-initiating ability of BP. 3-, 4-, and 12-methyl-benzo(a)pyrenes had activity equivalent to that of BP, whereas 2-, 5-, and 6-methylbenzo(a)pyrenes, as well as 1.2-, 4.5-, 1.6-, and 3.6-dimethylbenzo(a)pyrenes, were all less active than BP. The concepts of steric inhibition of metabolic activation and stereospecific activation are suggested to explain the tumor-initiating activities of various methylated derivatives.",
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AU - Iyer, R. P.

AU - Lyga, J. W.

AU - Secrist, J. A.

AU - Daub, G. H.

AU - Slaga, Thomas J

PY - 1980

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N2 - The abilities of various mono and dimethyl derivatives of benzo(a)pyrene (BP) to initiate skin tumors in mice were determined by using a 2-stage system of tumorigenesis. 11-Methylbenzo(a)pyrene was found to be approximately 3 times more active as a tumor initiator than was the parent hydrocarbon; 1-methyl benzo(a)pyrene was about twice as active as was BP. Substitution of a methyl group in positions 7, 8, 9, or 10 of BP, which would be involved in a bay-region diol-epoxide, completely counteracts the tumor-initiating ability of BP. 3-, 4-, and 12-methyl-benzo(a)pyrenes had activity equivalent to that of BP, whereas 2-, 5-, and 6-methylbenzo(a)pyrenes, as well as 1.2-, 4.5-, 1.6-, and 3.6-dimethylbenzo(a)pyrenes, were all less active than BP. The concepts of steric inhibition of metabolic activation and stereospecific activation are suggested to explain the tumor-initiating activities of various methylated derivatives.

AB - The abilities of various mono and dimethyl derivatives of benzo(a)pyrene (BP) to initiate skin tumors in mice were determined by using a 2-stage system of tumorigenesis. 11-Methylbenzo(a)pyrene was found to be approximately 3 times more active as a tumor initiator than was the parent hydrocarbon; 1-methyl benzo(a)pyrene was about twice as active as was BP. Substitution of a methyl group in positions 7, 8, 9, or 10 of BP, which would be involved in a bay-region diol-epoxide, completely counteracts the tumor-initiating ability of BP. 3-, 4-, and 12-methyl-benzo(a)pyrenes had activity equivalent to that of BP, whereas 2-, 5-, and 6-methylbenzo(a)pyrenes, as well as 1.2-, 4.5-, 1.6-, and 3.6-dimethylbenzo(a)pyrenes, were all less active than BP. The concepts of steric inhibition of metabolic activation and stereospecific activation are suggested to explain the tumor-initiating activities of various methylated derivatives.

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