Comparative structure and chemistry of tubulins from different eukaryotes

Richard F. Luduena, Melvyn Little

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Electrophoretic and peptide mapping have been used to examine α- and β-tubulins from chordates, tunicates, echinoderms, mollusks, brachiopods, ferns, fungi, green algae and heliozoans. Cytoplasmic, ciliary, flagellar, and axopodial tubulins were examined. The results show that β-tubulin is more conserved than α-tubulin. The large differences seen between axonemal and cytoplasmic tubulins and the similarity of all axonemal tubulins examined indicate that the genes for these two tubulin classes diverged prior to the appearance of metazoa and metaphyta. Comparisons of α-tubulins appear useful for tracing phyletic relationships within kingdoms whereas comparisons of β-tubulins may be better for relating the kingdoms to each other.

Original languageEnglish (US)
Pages (from-to)231-238
Number of pages8
JournalBioSystems
Volume14
Issue number3-4
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

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