Comparative structural analysis of human and rat 65 kDa tumor-associated phosphoproteins

Marek Mirowski, Zbigniew Walaszek, Ute Sherman, Malgorzata Hanausek

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

1. 1. A 65 kDa-tumor-associated protein (p65) was isolated from human and rat carcinoma cell culture media. Antibodies raised to the rat protein recognized an antigenically related protein in human cancer cell line. 2. 2. Amino acid composition, N-terminal and internal sequence as well as peptide map and western blot analysis of the p65 strongly suggest a high degree of homology between the human and rat p65 proteins. 3. 3. Homology searches indicated that p65 was not homologous to previously sequenced proteins, but that it may be related to proteins of the steroid receptor superfamily of genes, especially c-erb A gene.

Original languageEnglish (US)
Pages (from-to)1865-1871
Number of pages7
JournalInternational Journal of Biochemistry
Volume25
Issue number12
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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