Comparative in vitro activities of clarithromycin, azithromycin, and erythromycin against Borrelia burgdorferi

L. L. Dever, J. H. Jorgensen, A. G. Barbour

Research output: Contribution to journalComment/debate

37 Scopus citations

Abstract

The in vitro activities of the macrolide antibiotics clarithromycin, 14- hydroxy-clarithromycin, azithromycin, and erythromycin against 19 isolates of Borrelia burgdorferi were investigated. MICs ranged from 0.003 to 0.03 μg of clarithromycin per ml, 0.007 to 0.03 μg of 14-hydroxyclarithromycin per ml, 0.003 to 0.03 μg of azithromycin per ml, and 0.007 to 0.06 μg of erythromycin per ml. Time-kill studies using the B31 strain of B. burgdorferi demonstrated a ≥3-log10-unit killing after 72 h with each of the macrolide antibiotics tested in concentrations representing twice the respective MICs.

Original languageEnglish (US)
Pages (from-to)1704-1706
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume37
Issue number8
DOIs
StatePublished - Jan 1 1993

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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