Comparative biology of aging in birds: An update

D. J. Holmes, R. Flückiger, S. N. Austad

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo rapid to slow 'gradual' senescence. Some seabird species exhibit extremely slow age-related declines in both survival and reproductive output, and even increase reproductive success as they get older. Slow avian senescence is thought to be coupled evolutionarily with delayed maturity and low annual fecundity. Recent research in our lab and others supports the hypothesis that birds have special adaptations for preventing age-related tissue damage caused by reactive oxygen species (ROS) and advanced glycosylation endproducts, or AGEs, as well as an unusual capacity for neurogeneration in brain. Much of this work is in its early stages, however, and reliable biomarkers for comparing avian and mammalian aging need more thorough development.

Original languageEnglish (US)
Pages (from-to)869-883
Number of pages15
JournalExperimental Gerontology
Volume36
Issue number4-6
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Birds
Aging of materials
Glycosylation
Mammals
Life Tables
Biomarkers
Body Temperature
Fertility
Blood Glucose
Reactive Oxygen Species
Brain
Tissue
Research
Temperature

Keywords

  • Advanced glycosylation endoproducts
  • Aging
  • Birds
  • Glycosylation
  • Neurogeneration
  • Oxidative defenses
  • Reactive oxygen species
  • Senescence

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

Cite this

Comparative biology of aging in birds : An update. / Holmes, D. J.; Flückiger, R.; Austad, S. N.

In: Experimental Gerontology, Vol. 36, No. 4-6, 2001, p. 869-883.

Research output: Contribution to journalArticle

Holmes, DJ, Flückiger, R & Austad, SN 2001, 'Comparative biology of aging in birds: An update', Experimental Gerontology, vol. 36, no. 4-6, pp. 869-883. https://doi.org/10.1016/S0531-5565(00)00247-3
Holmes, D. J. ; Flückiger, R. ; Austad, S. N. / Comparative biology of aging in birds : An update. In: Experimental Gerontology. 2001 ; Vol. 36, No. 4-6. pp. 869-883.
@article{7c0ae024dcb94920a945281049fc4876,
title = "Comparative biology of aging in birds: An update",
abstract = "The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo rapid to slow 'gradual' senescence. Some seabird species exhibit extremely slow age-related declines in both survival and reproductive output, and even increase reproductive success as they get older. Slow avian senescence is thought to be coupled evolutionarily with delayed maturity and low annual fecundity. Recent research in our lab and others supports the hypothesis that birds have special adaptations for preventing age-related tissue damage caused by reactive oxygen species (ROS) and advanced glycosylation endproducts, or AGEs, as well as an unusual capacity for neurogeneration in brain. Much of this work is in its early stages, however, and reliable biomarkers for comparing avian and mammalian aging need more thorough development.",
keywords = "Advanced glycosylation endoproducts, Aging, Birds, Glycosylation, Neurogeneration, Oxidative defenses, Reactive oxygen species, Senescence",
author = "Holmes, {D. J.} and R. Fl{\"u}ckiger and Austad, {S. N.}",
year = "2001",
doi = "10.1016/S0531-5565(00)00247-3",
language = "English (US)",
volume = "36",
pages = "869--883",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",
number = "4-6",

}

TY - JOUR

T1 - Comparative biology of aging in birds

T2 - An update

AU - Holmes, D. J.

AU - Flückiger, R.

AU - Austad, S. N.

PY - 2001

Y1 - 2001

N2 - The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo rapid to slow 'gradual' senescence. Some seabird species exhibit extremely slow age-related declines in both survival and reproductive output, and even increase reproductive success as they get older. Slow avian senescence is thought to be coupled evolutionarily with delayed maturity and low annual fecundity. Recent research in our lab and others supports the hypothesis that birds have special adaptations for preventing age-related tissue damage caused by reactive oxygen species (ROS) and advanced glycosylation endproducts, or AGEs, as well as an unusual capacity for neurogeneration in brain. Much of this work is in its early stages, however, and reliable biomarkers for comparing avian and mammalian aging need more thorough development.

AB - The long life spans and slow aging rates of birds relative to mammals are paradoxical in view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which are predicted to be liabilities by current biochemical theories of aging. Available avian life-table data show that most birds undergo rapid to slow 'gradual' senescence. Some seabird species exhibit extremely slow age-related declines in both survival and reproductive output, and even increase reproductive success as they get older. Slow avian senescence is thought to be coupled evolutionarily with delayed maturity and low annual fecundity. Recent research in our lab and others supports the hypothesis that birds have special adaptations for preventing age-related tissue damage caused by reactive oxygen species (ROS) and advanced glycosylation endproducts, or AGEs, as well as an unusual capacity for neurogeneration in brain. Much of this work is in its early stages, however, and reliable biomarkers for comparing avian and mammalian aging need more thorough development.

KW - Advanced glycosylation endoproducts

KW - Aging

KW - Birds

KW - Glycosylation

KW - Neurogeneration

KW - Oxidative defenses

KW - Reactive oxygen species

KW - Senescence

UR - http://www.scopus.com/inward/record.url?scp=0035062170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035062170&partnerID=8YFLogxK

U2 - 10.1016/S0531-5565(00)00247-3

DO - 10.1016/S0531-5565(00)00247-3

M3 - Article

C2 - 11295520

AN - SCOPUS:0035062170

VL - 36

SP - 869

EP - 883

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

IS - 4-6

ER -