Comparative analysis of cell phenotypes in different severe clinical forms of Chagas' disease

Glenda M. Cardoso, M. J.F. Morato, J. A.S. Gomes, M. O.C. Rocha, I. P. Bonfim, S. Williams-Blangero, J. L. VandeBerg, M. R. Reis, E. F.L. Magalhães, Rodrigo Correa-Oliveira

    Research output: Contribution to journalArticle

    9 Scopus citations

    Abstract

    The understanding of the role of the immune response in the development of gastrointestinal and cardio-digestive (CD) forms of Chagas disease has received little attention. In this paper, the commitment of each leukocyte population of peripheral blood to the production of IFN-gamma, IMF-alpha, IL-12, IL-4, IL-5 and IL-10 was studied in patients with the CD form of Chagas disease. The data show that cells from patients with the CD form of the disease have distinct cytokine profiles when compared with the other clinical forms of Chagas disease and suggest that eosinophils are the major source of cytokine production in this clinical entity. The data presented in this paper demonstrate that patients with CD form can be distinguished from patients with gastrointestinal or cardiac forms of the disease by the distinct cytokine profile of peripheral blood cells.

    Original languageEnglish (US)
    Pages (from-to)1158-1163
    Number of pages6
    JournalFrontiers in Bioscience
    Volume11
    Issue number1 P.889-1198
    DOIs
    StatePublished - 2006

    Keywords

    • Blood
    • Cell
    • Chagas' disease
    • Clinical forms
    • Cytokine
    • Disease
    • Parasite

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Immunology and Microbiology(all)

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  • Cite this

    Cardoso, G. M., Morato, M. J. F., Gomes, J. A. S., Rocha, M. O. C., Bonfim, I. P., Williams-Blangero, S., VandeBerg, J. L., Reis, M. R., Magalhães, E. F. L., & Correa-Oliveira, R. (2006). Comparative analysis of cell phenotypes in different severe clinical forms of Chagas' disease. Frontiers in Bioscience, 11(1 P.889-1198), 1158-1163. https://doi.org/10.2741/1870