Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing

Richard T. O’Neil, Xiaojing Wang, Michael V. Morabito, Ronald B. Emeson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A-to-I RNA editing is an important process for generating molecular diversity in the brain through modification of transcripts encoding several proteins important for neuronal signaling. We investigated the relationships between the extent of editing at multiple substrate transcripts (5HT2C, MGLUR4, CADPS, GLUR2, GLUR4, and GABRA3) in brain tissue obtained from adult humans and rhesus macaques. Several patterns emerged from these studies revealing conservation of editing across primate species. Additionally, variability in the human population allows us to make novel inferences about the co-regulation of editing at different editing sites and even across different brain regions.

Original languageEnglish (US)
Article number11
JournalMolecular Brain
Volume10
Issue number1
DOIs
StatePublished - Apr 6 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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