Comorbidity of migraine and major affective disorders

Naomi Breslau, Kathleen Merikangas, Charles L. Bowden

Research output: Contribution to journalArticlepeer-review

173 Scopus citations


Two epidemiologic studies of young adults from the Detroit metropolitan area and from Zurich, Switzerland, focused on the relationship between migraine and affective disorders, such as major depression, dys- thymia, bipolar disorder, and cyclothymia. Through application of current definitions of migraine and psychiatric disorders in structured diagnostic interviews, data have been obtained that strongly support clinical observations on migraine-major depression comorbidity. The findings to support a link between migraine and bipolar disorder are less consistent. Physicians caring for patients with migraine or affective disorders should maintain diagnostic vigilance for comorbid disease and, when present, should consider comorbidity in planning treatment interventions.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
Issue number10
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Clinical Neurology


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