Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians

Barbora Vozarova De Courten, Robert L. Hanson, Tohru Funahashi, Robert S. Lindsay, Yuji Matsuzawa, Sachiyo Tanaka, Farook Thameem, Jonathan D. Gruber, Philippe Froguel, Johanna K. Wolford

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the adiponectin gene ACDC have been previously associated with plasma adiponectin levels, obesity, insulin resistance, and type 2 diabetes. To determine the role of genetic variation in ACDC in susceptibility to obesity and type 2 diabetes in Pima Indians, we screened the promoter, exons, and exon-intron boundaries of the gene to identify allelic variants. We identified 17 informative polymorphisms that comprised four common (minor allele frequency >15%) linkage disequilibrium clusters consisting of 1-4 variants each. We genotyped one representative polymorphism from each cluster in 1,338 individuals and assessed genotypic association with type 2 diabetes, BMI, serum lipid levels, serum adiponectin levels, and measures of insulin sensitivity and secretion. None of the ACDC variants were associated with type 2 diabetes, BMI, or measures of insulin sensitivity or secretion. One variant, single nucleotide polymorphism (SNP)-12823, was associated with serum adiponectin levels (P = 0.002), but this association explained only 2% of the variance of serum adiponectin levels. Our findings suggest that these common ACDC polymorphisms do not play a major role in susceptibility to obesity or type 2 diabetes in this population.

Original languageEnglish (US)
Pages (from-to)284-289
Number of pages6
JournalDiabetes
Volume54
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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