Common pathways of depression and pain

Pedro L. Delgado

Research output: Contribution to journalReview article

107 Scopus citations


Depressive disorders are chronic conditions that produce both emotional and physical symptoms. Increasing evidence suggests that in some patients with depressive disorders a neurodegenerative process may occur, highlighting the importance of early and aggressive intervention. Serotonin (5-HT) and norepinephrine (NE) neurotransmitter systems influence neuroplasticity in the brain, and both are involved in mediating the therapeutic effects of most currently available antidepressants. Some dual-action antidepressants have been shown to be effective in managing the pain symptoms associated with depression. These agents may have advantages over others by treating a wider array of physical symptoms. Additionally, these agents may also have a role in modulating neurogenesis and other neuroplastic changes, thereby leading to more complete recovery in patients suffering from the emotional and physical symptoms of chronic depression.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 12
StatePublished - Dec 1 2004


ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Delgado, P. L. (2004). Common pathways of depression and pain. Journal of Clinical Psychiatry, 65(SUPPL. 12), 16-19.