Common neurogenetic diagnosis and meso-limbic manipulation of hypodopaminergic function in reward deficiency syndrome (RDS): Changing the recovery landscape

Kenneth Blum, Marcelo Febo, Rajendra D. Badgaiyan, Zsolt Demetrovics, Thomas Simpatico, Claudia Fahlke, M. Oscar-Berman, Mona Li, Kristina Dushaj, Mark S. Gold

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Background: In 1990, Blum and associates provided the first confirmed genetic link between the DRD2 polymorphisms and alcoholism. This finding was based on an earlier conceptual framework, which served as a blueprint for their seminal genetic association discovery they termed “Brain Reward Cascade.” These findings were followed by a new way of understanding all addictive behaviors (substance and non-substance) termed “Reward Deficiency Syndrome” (RDS). RDS incorporates a complex multifaceted array of inheritable behaviors that are polygenic. Objective: In this review article, we attempt to clarify these terms and provide a working model to accurately diagnose and treat these unwanted behaviors. Method: We are hereby proposing the development of a translational model we term "Reward Deficiency Solution System™" that incorporates neurogenetic testing and meso-limbic manipulation of a “hypodopaminergic” trait/state, which provides dopamine agonistic therapy (DAT) as well as reduced “dopamine resistance,” while embracing “dopamine homeostasis.” Result: The result is better recovery and relapse prevention, despite DNA antecedents, which could impact the recovery process and relapse. Understanding the commonality of mental illness will transform erroneous labeling based on symptomatology, into a genetic and anatomical etiology. WC: 184.

Original languageEnglish (US)
Pages (from-to)184-194
Number of pages11
JournalCurrent Neuropharmacology
Volume15
Issue number1
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Dopamine homeostasis
  • Genetics
  • Reward deficiency solution system
  • Reward deficiency syndrome (RDS)

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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