Common and uncommon histologic subtypes of renal cell carcinoma: Imaging spectrum with pathologic correlation

Srinivasa R. Prasad, Peter A. Humphrey, Jay R. Catena, Vamsi R. Narra, John R. Srigley, Arthur D. Cortez, Neal C. Dalrymple, Kedar N. Chintapalli

Research output: Contribution to journalReview articlepeer-review

207 Scopus citations

Abstract

Renal cell carcinoma (RCC) is a cause of significant morbidity and mortality, with an estimated 35,000 new cases and 12,480 deaths in the United States in 2003. Recent advances in imaging technology, pathology, urology, and oncology permit early diagnosis of RCC and facilitate optimal management. The 2004 World Health Organization classification for renal neoplasms recognizes several distinct histologic subtypes of RCC. These subtypes include clear cell RCC, papillary RCC, chromophobe RCC, hereditary cancer syndromes, multilocular cystic RCC, collecting duct carcinoma, medullary carcinoma, mucinous tubular and spindle cell carcinoma, neuroblastoma-associated RCC, Xp11.2 translocation-TFE3 carcinoma, and unclassified lesions. Different histologic subtypes of RCC have characteristic histomorphologic and biologic profiles. Clear cell RCC is the most common subtype and has a less favorable prognosis (stage for stage) than do papillary RCC and chromophobe RCC. Collecting duct carcinoma and renal medullary carcinoma are associated with aggressive clinical behavior and a poor prognosis.

Original languageEnglish (US)
Pages (from-to)1795-1806
Number of pages12
JournalRadiographics
Volume26
Issue number6
DOIs
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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