Commercially motivated renal transplantation: Results in 540 patients transplanted in India

Wajeh Y Qunibi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)536-544
Number of pages9
JournalClinical Transplantation
Volume11
Issue number6
StatePublished - Dec 1997
Externally publishedYes

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Kidney Transplantation
India
Graft Survival
Virus Diseases
Transplants
Survival Rate
Transplantation
Middle East
Incidence
Immunosuppressive Agents
Hepatitis B virus
Tertiary Care Centers
Renal Dialysis
Demography
Viruses
Kidney
Infection

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Commercially motivated renal transplantation : Results in 540 patients transplanted in India. / Qunibi, Wajeh Y.

In: Clinical Transplantation, Vol. 11, No. 6, 12.1997, p. 536-544.

Research output: Contribution to journalArticle

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title = "Commercially motivated renal transplantation: Results in 540 patients transplanted in India",
abstract = "Commercial renal transplantation is widely condemned on moral and ethical grounds. Moreover, previous studies involving small numbers of patients, mostly from tertiary care centers, have reported poor patient and graft survival. The Living Non-Related Renal Transplant Study Group was established to determine the overall results and complications in a large number of patients who received this type of transplantation in India. In this study we retrospectively collected data from 22 centers on 540 patients who had received commercial renal transplantation (CRT) in India between 1978 and 1993. The data collected included demographic characteristics of patients, the primary renal disease, dialysis and pretransplant data, immunosuppressive regimen, rejection episodes, post-transplant data, as well as patient and graft outcomes. Results were compared with those of 75 recipients of emotionally related renal transplantation (ERT) performed in two participating institutions in the Middle East. Among the 540 patients, 7.5{\%} were younger than 20 yr of age and 14.2{\%} were 50 yr of age or older. After adjusting for several variables, the 1-, 3-, and 5-yr patient survival rates in the CRT were 97, 94, and 92{\%}, and in the ERT 95, 91, and 91{\%} respectively (p = 0.4921). The corresponding rates for graft survival were 90, 81, and 72{\%}, and 90, 86, and 83{\%}, respectively (p = 0.5336). There was a higher incidence of human immune deficiency virus (HIV) infection (4.6{\%} vs. 0{\%} p = 0.053), and hepatitis B virus (HbsAg) infection rate (8.1{\%} vs. 1.4{\%} p = 0.03) in CRT. In conclusion, patient and graft survival rates in recipients of commercial renal transplantation are similar to those in recipients of emotionally related transplantation done in our institutions. However, the incidence of serious infections with HIV and HbsAg is significantly higher.",
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