Combinations of 5-FU, hypoxanthine, and allopurinol in chemotherapy for human colon adenocarcinoma xenografts

J. A. Houghton, P. J. Houghton

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A series of four human colon adenocarcinomas, growing as xenografts in immune-deprived mice, have been used to evaluate the efficacy of 5-FU in combination with two purines, hypoxanthine (Hx) and allopurinol (HPP), which have reduced the toxicity of 5-FU in host mice. Tumor-bearing mice were treated at 7-day intervals with 5-FU administered simultaneously with the protecting agents (Hx and HPP). Two tumor lines (HxVRC5 and HxGC3), insensitive to 5-FU alone, failed to show any response to this combination. In 5-FU-sensitive HxELC2 tumors, the combination of 5-FU with Hx and HPP did not increase the therapeutic index, and in HxHC1 xenografts, antagonism to 5-FU cytotoxicity was observed. Tumor response in relation to the pathways of 5-FU metabolism is discussed.

Original languageEnglish (US)
Pages (from-to)1201-1206
Number of pages6
JournalCancer Treatment Reports
Volume66
Issue number5
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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