Combination Treatments for Schizophrenia

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Combination treatments, especially combinations of antipsychotics, are used frequently for schizophrenia, despite a paucity of evidence regarding their safety and efficacy. Because the literature basis is weak and expert recommendations are largely lacking, providers should be vigilant in documenting improved outcomes for patients thought to benefit from combination treatments. Target symptoms that have been studied include psychosis, cognitive deficits, and negative symptoms. The strongest evidence is for augmentation of clozapine with another antipsychotic or with electroconvulsive therapy for persistent positive symptoms. Combination treatments for cognitive deficits and negative symptoms are being actively investigated, but current evidence is insufficient to recommend available agents for these components of schizophrenia. It is important that appropriate monotherapies be given adequate trials before resorting to combination therapies.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalCNS spectrums
Issue numberS9
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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