Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis

William R. Kirkpatrick, Ana C. Vallor, Robert K. McAtee, Neil S. Ryder, Annette W. Fothergill, Michael G. Rinaldi, Thomas F. Patterson

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.

Original languageEnglish (US)
Pages (from-to)4751-4753
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume49
Issue number11
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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