Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis

William R. Kirkpatrick; Ana C. Vallor; Robert K. McAtee; Neil S. Ryder; Annette W. Fothergill; Michael G. Rinaldi; Thomas F. Patterson

doi:10.1128/AAC.49.11.4751-4753.2005

Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis

William R. Kirkpatrick, Ana C. Vallor, Robert K. McAtee, Neil S. Ryder, Annette W. Fothergill, Michael G. Rinaldi, Thomas F. Patterson

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.

Original language	English (US)
Pages (from-to)	4751-4753
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	49
Issue number	11
DOIs	https://doi.org/10.1128/AAC.49.11.4751-4753.2005
State	Published - Nov 2005

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/AAC.49.11.4751-4753.2005

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title = "Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis",

abstract = "Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.",

author = "Kirkpatrick, {William R.} and Vallor, {Ana C.} and McAtee, {Robert K.} and Ryder, {Neil S.} and Fothergill, {Annette W.} and Rinaldi, {Michael G.} and Patterson, {Thomas F.}",

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AU - Kirkpatrick, William R.

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AU - McAtee, Robert K.

AU - Ryder, Neil S.

AU - Fothergill, Annette W.

AU - Rinaldi, Michael G.

AU - Patterson, Thomas F.

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AB - Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.

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Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis

Abstract

ASJC Scopus subject areas

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