Combination therapy of experimental histoplasmosis and cryptococcosis with amphotericin B and ketoconazole.

J. R. Graybill, D. M. Williams, E. Van Cutsem, D. J. Drutz

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Combinations of amphotericin B and ketoconazole had an additive effect in vitro against Histoplasma capsulatum and Cryptococcus neoformans; ketoconazole combined with flucytosine exerted an indifferent effect against C. neoformans. In vivo studies in athymic nude (nu/nu) mice and their heterozygous (nu/+) littermates demonstrated that treatment with the ketoconazole-amphotericin B combination resulted in longer survival of mice with cryptococcosis than did treatment with ketoconazole plus flucytosine. However, mice given ketoconazole plus amphotericin B did not survive significantly longer than those given amphotericin B alone (cryptococcosis) or ketoconazole alone (histoplasmosis). Combination chemotherapy with ketoconazole and amphotericin B may offer a modest therapeutic advantage over therapy with either drug alone.

Original languageEnglish (US)
Pages (from-to)551-558
Number of pages8
JournalReviews of Infectious Diseases
Volume2
Issue number4
StatePublished - Jul 1980
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

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