Combination therapy in the treatment of experimental invasive fungal infection by Sarocladium (Acremonium) kiliense

Fabiola Fernández-Silva; Javier Capilla; Emilio Mayayo; Deanna Sutton; Josep Guarro

doi:10.1016/j.ijantimicag.2014.03.010

Combination therapy in the treatment of experimental invasive fungal infection by Sarocladium (Acremonium) kiliense

Fabiola Fernández-Silva, Javier Capilla, Emilio Mayayo, Deanna Sutton, Josep Guarro

Pathology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Since human infections by Sarocladium (Acremonium) kiliense are usually refractory to antifungal therapy, combinations of drugs are an option that needs exploring. The antifungal activities of anidulafungin plus posaconazole or voriconazole and of amphotericin B plus voriconazole were evaluated and their efficacy was tested in a murine model of disseminated infection by three S. kiliense strains. The results showed that although efficacy was strain-dependent, these combinations work better, in general, than monotherapies. The best results were obtained with the combination of anidulafungin plus posaconazole, although the in vitro assay showed indifference or an antagonistic effect.

Original language	English (US)
Pages (from-to)	136-139
Number of pages	4
Journal	International Journal of Antimicrobial Agents
Volume	44
Issue number	2
DOIs	https://doi.org/10.1016/j.ijantimicag.2014.03.010
State	Published - Aug 2014

Keywords

Animal model
Antifungal combinations
Fungal infection
Sarocladium kiliense

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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abstract = "Since human infections by Sarocladium (Acremonium) kiliense are usually refractory to antifungal therapy, combinations of drugs are an option that needs exploring. The antifungal activities of anidulafungin plus posaconazole or voriconazole and of amphotericin B plus voriconazole were evaluated and their efficacy was tested in a murine model of disseminated infection by three S. kiliense strains. The results showed that although efficacy was strain-dependent, these combinations work better, in general, than monotherapies. The best results were obtained with the combination of anidulafungin plus posaconazole, although the in vitro assay showed indifference or an antagonistic effect.",

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AU - Sutton, Deanna

AU - Guarro, Josep

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