TY - JOUR
T1 - Combination therapy in the treatment of experimental invasive fungal infection by Sarocladium (Acremonium) kiliense
AU - Fernández-Silva, Fabiola
AU - Capilla, Javier
AU - Mayayo, Emilio
AU - Sutton, Deanna
AU - Guarro, Josep
PY - 2014/8
Y1 - 2014/8
N2 - Since human infections by Sarocladium (Acremonium) kiliense are usually refractory to antifungal therapy, combinations of drugs are an option that needs exploring. The antifungal activities of anidulafungin plus posaconazole or voriconazole and of amphotericin B plus voriconazole were evaluated and their efficacy was tested in a murine model of disseminated infection by three S. kiliense strains. The results showed that although efficacy was strain-dependent, these combinations work better, in general, than monotherapies. The best results were obtained with the combination of anidulafungin plus posaconazole, although the in vitro assay showed indifference or an antagonistic effect.
AB - Since human infections by Sarocladium (Acremonium) kiliense are usually refractory to antifungal therapy, combinations of drugs are an option that needs exploring. The antifungal activities of anidulafungin plus posaconazole or voriconazole and of amphotericin B plus voriconazole were evaluated and their efficacy was tested in a murine model of disseminated infection by three S. kiliense strains. The results showed that although efficacy was strain-dependent, these combinations work better, in general, than monotherapies. The best results were obtained with the combination of anidulafungin plus posaconazole, although the in vitro assay showed indifference or an antagonistic effect.
KW - Animal model
KW - Antifungal combinations
KW - Fungal infection
KW - Sarocladium kiliense
UR - http://www.scopus.com/inward/record.url?scp=84905582335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905582335&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2014.03.010
DO - 10.1016/j.ijantimicag.2014.03.010
M3 - Article
C2 - 24837411
AN - SCOPUS:84905582335
VL - 44
SP - 136
EP - 139
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 2
ER -