Combination antibiotics and indomethacin in idiopathic preterm labor: A randomized double-blind clinical trial

Edward R. Newton, Laurence Shields, Louis E. Ridgway, Michael D. Berkus, Byron D. Elliott

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Subclinical infection may play a role in the failure of magnesium sulfate tocolysis. Using a double-blind randomized study design, we administered a combination of ampicillin-sulbactam and indomethacin or corresponding placebos to patients in preterm labor who were receiving intravenous magnesium sulfate tocolysis. The mean gestational age at enrollment was 30.1 weeks, and mean cervical dilatation was 2.15 cm. No differences were noted between placebo (n = 43) and study patients (n = 43) in gestational age at delivery, term deliveries, days gained, or neonatal outcome. Preterm delivery (< 36 weeks) occurred in 61% of the total population. The likelihood of a β error was 0.07 to 0.23 on the basis of outcome analysis. In our population adjunctive ampicillin-sulbactam with indomethacin did not improve the success of magnesium sulfate tocolysis.

Original languageEnglish (US)
Pages (from-to)1753-1759
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume165
Issue number6 PART 1
DOIs
StatePublished - Dec 1991

Keywords

  • Preterm labor
  • antibiotics
  • indomethacin

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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