Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer; Clinton K. Murray; Ian R. Driscoll; Brian L. Wickes; Nathan Wiederhold; Deanna A. Sutton; Carmita Sanders; Katrin Mende; Brent Enniss; James Feig; Anuradha Ganesan; Elizabeth A. Rini; Todd J. Vento

doi:10.1128/JCM.00410-15

Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer
, Clinton K. Murray
, Ian R. Driscoll
, Brian L. Wickes
, Nathan Wiederhold
, Deanna A. Sutton
, Carmita Sanders
, Katrin Mende
, Brent Enniss
, James Feig
, Anuradha Ganesan
, Elizabeth A. Rini
, Todd J. Vento

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

Original language	English (US)
Pages (from-to)	1968-1975
Number of pages	8
Journal	Journal of clinical microbiology
Volume	53
Issue number	6
DOIs	https://doi.org/10.1128/JCM.00410-15
State	Published - Jun 1 2015

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/JCM.00410-15

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Farmer, A. R., Murray, C. K., Driscoll, I. R., Wickes, B. L., Wiederhold, N., Sutton, D. A., Sanders, C., Mende, K., Enniss, B., Feig, J., Ganesan, A., Rini, E. A., & Vento, T. J. (2015). Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics. Journal of clinical microbiology, 53(6), 1968-1975. https://doi.org/10.1128/JCM.00410-15

Farmer, AR, Murray, CK, Driscoll, IR, Wickes, BL, Wiederhold, N, Sutton, DA, Sanders, C, Mende, K, Enniss, B, Feig, J, Ganesan, A, Rini, EA & Vento, TJ 2015, 'Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics', Journal of clinical microbiology, vol. 53, no. 6, pp. 1968-1975. https://doi.org/10.1128/JCM.00410-15

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title = "Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics",

abstract = "We describe a 22-year-old soldier with 19\% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.",

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AU - Wickes, Brian L.

AU - Wiederhold, Nathan

AU - Sutton, Deanna A.

AU - Sanders, Carmita

AU - Mende, Katrin

AU - Enniss, Brent

AU - Feig, James

AU - Ganesan, Anuradha

AU - Rini, Elizabeth A.

AU - Vento, Todd J.

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AB - We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

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Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Abstract

ASJC Scopus subject areas

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