Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer; Clinton K. Murray; Ian R. Driscoll; Brian L. Wickes; Nathan Wiederhold; Deanna A. Sutton; Carmita Sanders; Katrin Mende; Brent Enniss; James Feig; Anuradha Ganesan; Elizabeth A. Rini; Todd J. Vento

doi:10.1128/JCM.00410-15

Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer, Clinton K. Murray, Ian R. Driscoll, Brian L. Wickes, Nathan Wiederhold, Deanna A. Sutton, Carmita Sanders, Katrin Mende, Brent Enniss, James Feig, Anuradha Ganesan, Elizabeth A. Rini, Todd J. Vento

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32 Scopus citations

Abstract

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

Original language	English (US)
Pages (from-to)	1968-1975
Number of pages	8
Journal	Journal of clinical microbiology
Volume	53
Issue number	6
DOIs	https://doi.org/10.1128/JCM.00410-15
State	Published - Jun 1 2015

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/JCM.00410-15

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Farmer, A. R., Murray, C. K., Driscoll, I. R., Wickes, B. L., Wiederhold, N., Sutton, D. A., Sanders, C., Mende, K., Enniss, B., Feig, J., Ganesan, A., Rini, E. A., & Vento, T. J. (2015). Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics. Journal of clinical microbiology, 53(6), 1968-1975. https://doi.org/10.1128/JCM.00410-15

Farmer, AR, Murray, CK, Driscoll, IR, Wickes, BL, Wiederhold, N, Sutton, DA, Sanders, C, Mende, K, Enniss, B, Feig, J, Ganesan, A, Rini, EA & Vento, TJ 2015, 'Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics', Journal of clinical microbiology, vol. 53, no. 6, pp. 1968-1975. https://doi.org/10.1128/JCM.00410-15

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abstract = "We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.",

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AU - Sutton, Deanna A.

AU - Sanders, Carmita

AU - Mende, Katrin

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AU - Ganesan, Anuradha

AU - Rini, Elizabeth A.

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AB - We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

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Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Abstract

ASJC Scopus subject areas

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