Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer, Clinton K. Murray, Ian R. Driscoll, Brian L Wickes, Nathan Wiederhold, Deanna A. Sutton, Carmita Sanders, Katrin Mende, Brent Enniss, James Feig, Anuradha Ganesan, Elizabeth A. Rini, Todd J. Vento

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Abstract

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

Original languageEnglish (US)
Pages (from-to)1968-1975
Number of pages8
JournalJournal of Clinical Microbiology
Volume53
Issue number6
DOIs
StatePublished - Jun 1 2015

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ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Farmer, A. R., Murray, C. K., Driscoll, I. R., Wickes, B. L., Wiederhold, N., Sutton, D. A., Sanders, C., Mende, K., Enniss, B., Feig, J., Ganesan, A., Rini, E. A., & Vento, T. J. (2015). Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics. Journal of Clinical Microbiology, 53(6), 1968-1975. https://doi.org/10.1128/JCM.00410-15