Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer, Clinton K. Murray, Ian R. Driscoll, Brian L Wickes, Nathan Wiederhold, Deanna A. Sutton, Carmita Sanders, Katrin Mende, Brent Enniss, James Feig, Anuradha Ganesan, Elizabeth A. Rini, Todd J. Vento

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

Original languageEnglish (US)
Pages (from-to)1968-1975
Number of pages8
JournalJournal of Clinical Microbiology
Volume53
Issue number6
DOIs
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Microbiology (medical)

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    Farmer, A. R., Murray, C. K., Driscoll, I. R., Wickes, B. L., Wiederhold, N., Sutton, D. A., Sanders, C., Mende, K., Enniss, B., Feig, J., Ganesan, A., Rini, E. A., & Vento, T. J. (2015). Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics. Journal of Clinical Microbiology, 53(6), 1968-1975. https://doi.org/10.1128/JCM.00410-15