Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells

Sabitha Aligeti; Nameer B. Kirma; Peter A. Binkley; Robert S. Schenken; Rajeshwar Rao Tekmal

doi:10.1016/j.fertnstert.2011.03.026

Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells

Sabitha Aligeti
, Nameer B. Kirma
, Peter A. Binkley
, Robert S. Schenken
, Rajeshwar Rao Tekmal

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.

Original language	English (US)
Pages (from-to)	2464-2466
Number of pages	3
Journal	Fertility and sterility
Volume	95
Issue number	8
DOIs	https://doi.org/10.1016/j.fertnstert.2011.03.026
State	Published - Jun 30 2011

Keywords

Colony-stimulating factor 1
c-fms
early lesion development
endometriosis

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2011.03.026

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title = "Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells",

abstract = "Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.",

keywords = "Colony-stimulating factor 1, c-fms, early lesion development, endometriosis",

author = "Sabitha Aligeti and Kirma, \{Nameer B.\} and Binkley, \{Peter A.\} and Schenken, \{Robert S.\} and Tekmal, \{Rajeshwar Rao\}",

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T1 - Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells

AU - Aligeti, Sabitha

AU - Kirma, Nameer B.

AU - Binkley, Peter A.

AU - Schenken, Robert S.

AU - Tekmal, Rajeshwar Rao

PY - 2011/6/30

Y1 - 2011/6/30

N2 - Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.

AB - Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.

KW - Colony-stimulating factor 1

KW - c-fms

KW - early lesion development

KW - endometriosis

UR - https://www.scopus.com/pages/publications/79959728180

UR - https://www.scopus.com/pages/publications/79959728180#tab=citedBy

U2 - 10.1016/j.fertnstert.2011.03.026

DO - 10.1016/j.fertnstert.2011.03.026

M3 - Article

C2 - 21481374

AN - SCOPUS:79959728180

SN - 0015-0282

VL - 95

SP - 2464

EP - 2466

JO - Fertility and sterility

JF - Fertility and sterility

IS - 8

ER -

Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells

Abstract

Keywords

ASJC Scopus subject areas

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