Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells

Sabitha Aligeti, Nameer B. Kirma, Peter A. Binkley, Robert S. Schenken, Rajeshwar Rao Tekmal

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.

Original languageEnglish (US)
Pages (from-to)2464-2466
Number of pages3
JournalFertility and Sterility
Volume95
Issue number8
DOIs
StatePublished - Jun 30 2011

Keywords

  • Colony-stimulating factor 1
  • c-fms
  • early lesion development
  • endometriosis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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