Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis infection

Yaíma L. Lightfoot; Tao Yang; Bikash Sahay; Mojgan Zadeh; Sam X. Cheng; Gary P. Wang; Jennifer L. Owen; Mansour Mohamadzadeh

doi:10.1371/journal.pone.0100532

Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis infection

Yaíma L. Lightfoot, Tao Yang, Bikash Sahay, Mojgan Zadeh, Sam X. Cheng, Gary P. Wang, Jennifer L. Owen, Mansour Mohamadzadeh

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Gastrointestinal (GI) anthrax results from the ingestion of Bacillus anthracis. Herein, we investigated the pathogenesis of GI anthrax in animals orally infected with toxigenic non-encapsulated B. anthracis Sterne strain (pXO1⁺ pXO2^-) spores that resulted in rapid animal death. B. anthracis Sterne induced significant breakdown of intestinal barrier function and led to gut dysbiosis, resulting in systemic dissemination of not only B. anthracis, but also of commensals. Disease progression significantly correlated with the deterioration of innate and T cell functions. Our studies provide critical immunologic and physiologic insights into the pathogenesis of GI anthrax infection, whereupon cleavage of mitogen-activated protein kinases (MAPKs) in immune cells may play a central role in promoting dysfunctional immune responses against this deadly pathogen. Copyright:

Original language	English (US)
Article number	e100532
Journal	PloS one
Volume	9
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0100532
State	Published - Jun 19 2014
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1371/journal.pone.0100532

Cite this

@article{ec8d8e5eb1584879b7ec7c202ecd6978,

title = "Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis infection",

abstract = "Gastrointestinal (GI) anthrax results from the ingestion of Bacillus anthracis. Herein, we investigated the pathogenesis of GI anthrax in animals orally infected with toxigenic non-encapsulated B. anthracis Sterne strain (pXO1+ pXO2-) spores that resulted in rapid animal death. B. anthracis Sterne induced significant breakdown of intestinal barrier function and led to gut dysbiosis, resulting in systemic dissemination of not only B. anthracis, but also of commensals. Disease progression significantly correlated with the deterioration of innate and T cell functions. Our studies provide critical immunologic and physiologic insights into the pathogenesis of GI anthrax infection, whereupon cleavage of mitogen-activated protein kinases (MAPKs) in immune cells may play a central role in promoting dysfunctional immune responses against this deadly pathogen. Copyright:",

author = "Lightfoot, {Ya{\'i}ma L.} and Tao Yang and Bikash Sahay and Mojgan Zadeh and Cheng, {Sam X.} and Wang, {Gary P.} and Owen, {Jennifer L.} and Mansour Mohamadzadeh",

year = "2014",

month = jun,

day = "19",

doi = "10.1371/journal.pone.0100532",

language = "English (US)",

volume = "9",

journal = "PloS one",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "6",

}

TY - JOUR

T1 - Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis infection

AU - Lightfoot, Yaíma L.

AU - Yang, Tao

AU - Sahay, Bikash

AU - Zadeh, Mojgan

AU - Cheng, Sam X.

AU - Wang, Gary P.

AU - Owen, Jennifer L.

AU - Mohamadzadeh, Mansour

PY - 2014/6/19

Y1 - 2014/6/19

N2 - Gastrointestinal (GI) anthrax results from the ingestion of Bacillus anthracis. Herein, we investigated the pathogenesis of GI anthrax in animals orally infected with toxigenic non-encapsulated B. anthracis Sterne strain (pXO1+ pXO2-) spores that resulted in rapid animal death. B. anthracis Sterne induced significant breakdown of intestinal barrier function and led to gut dysbiosis, resulting in systemic dissemination of not only B. anthracis, but also of commensals. Disease progression significantly correlated with the deterioration of innate and T cell functions. Our studies provide critical immunologic and physiologic insights into the pathogenesis of GI anthrax infection, whereupon cleavage of mitogen-activated protein kinases (MAPKs) in immune cells may play a central role in promoting dysfunctional immune responses against this deadly pathogen. Copyright:

AB - Gastrointestinal (GI) anthrax results from the ingestion of Bacillus anthracis. Herein, we investigated the pathogenesis of GI anthrax in animals orally infected with toxigenic non-encapsulated B. anthracis Sterne strain (pXO1+ pXO2-) spores that resulted in rapid animal death. B. anthracis Sterne induced significant breakdown of intestinal barrier function and led to gut dysbiosis, resulting in systemic dissemination of not only B. anthracis, but also of commensals. Disease progression significantly correlated with the deterioration of innate and T cell functions. Our studies provide critical immunologic and physiologic insights into the pathogenesis of GI anthrax infection, whereupon cleavage of mitogen-activated protein kinases (MAPKs) in immune cells may play a central role in promoting dysfunctional immune responses against this deadly pathogen. Copyright:

UR - http://www.scopus.com/inward/record.url?scp=84903166568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903166568&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0100532

DO - 10.1371/journal.pone.0100532

M3 - Article

C2 - 24945934

AN - SCOPUS:84903166568

SN - 1932-6203

VL - 9

JO - PloS one

JF - PloS one

IS - 6

M1 - e100532

ER -

Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis infection

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this