Collection of pedigree data for genetic analysis in isolate populations

Sarah Williams-Blangero, John Blangero

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pedigree data are useful for a wealth of research purposes in human population biology and genetics. The collection of extended pedigrees represents the most powerful sampling design for quantitative genetic and linkage studies of both normal and disease-related quantitative traits. In this paper we outline an approach for collecting pedigree data in stable isolate populations. As an example, the pedigree for the Jirel population, which was obtained using the methods presented, is described. The Jirel pedigree contains 2,000 study participants and more than 62,000 pairwise relationships that are informative for genetic analysis. Once such pedigrees are genetically characterized by a genome scan for a given trait, they become an invaluable resource for future genetic studies of any quantitative trait.

Original languageEnglish (US)
Pages (from-to)89-101
Number of pages13
JournalHuman Biology
Volume78
Issue number1
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

genetic analysis
Pedigree
pedigree
genetic techniques and protocols
Population
quantitative traits
genome
Genetic Linkage
quantitative genetics
Population Genetics
Population Dynamics
sampling
resource
human population
linkage (genetics)
Genome
Biological Sciences
Research

Keywords

  • Data collection
  • Extended families
  • Fieldwork
  • Genetic epidemiology
  • Methods

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Williams-Blangero, S., & Blangero, J. (2006). Collection of pedigree data for genetic analysis in isolate populations. Human Biology, 78(1), 89-101.

Collection of pedigree data for genetic analysis in isolate populations. / Williams-Blangero, Sarah; Blangero, John.

In: Human Biology, Vol. 78, No. 1, 02.2006, p. 89-101.

Research output: Contribution to journalArticle

Williams-Blangero, S & Blangero, J 2006, 'Collection of pedigree data for genetic analysis in isolate populations', Human Biology, vol. 78, no. 1, pp. 89-101.
Williams-Blangero S, Blangero J. Collection of pedigree data for genetic analysis in isolate populations. Human Biology. 2006 Feb;78(1):89-101.
Williams-Blangero, Sarah ; Blangero, John. / Collection of pedigree data for genetic analysis in isolate populations. In: Human Biology. 2006 ; Vol. 78, No. 1. pp. 89-101.
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