Collagen and collagen-derived fragments are chemotactic for tumor cells

G. R. Mundy, S. DeMartino, D. W. Rowe

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

Organs that are rich in collagen such as liver, lungs, and bone are frequently sites of tumor cell metastasis. In this study, we have found that cultured tumor cells of human and rat origin migrated unidirectionally in response to collagen in vitro. Synthetic di- and tripeptides that contained amino acid sequences found frequently in the collagen helix caused similar effects. These results are consistent with the hypothesis that collagen or collagen fragments released during connective tissue remodeling may be important in tumor cell metastasis.

Original languageEnglish (US)
Pages (from-to)1102-1105
Number of pages4
JournalJournal of Clinical Investigation
Volume68
Issue number4
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Medicine(all)

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