Coinfections in Patients with Cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) Study

Gowri Satyanarayana, Kyle T. Enriquez, Tianyi Sun, Elizabeth J. Klein, Maheen Abidi, Shailesh M. Advani, Joy Awosika, Ziad Bakouny, Babar Bashir, Stephanie Berg, Marilia Bernardes, Pamela C. Egan, Arielle Elkrief, Lawrence E. Feldman, Christopher R. Friese, Shipra Goel, Cyndi Gonzalez Gomez, Keith L. Grant, Elizabeth A. Griffiths, Shuchi GulatiShilpa Gupta, Clara Hwang, Jayanshu Jain, Chinmay Jani, Anna Kaltsas, Anup Kasi, Hina Khan, Natalie Knox, Vadim S. Koshkin, Daniel H. Kwon, Chris Labaki, Gary H. Lyman, Rana R. McKay, Christopher McNair, Gayathri Nagaraj, Elizabeth S. Nakasone, Ryan Nguyen, Taylor K. Nonato, Adam J. Olszewski, Orestis A. Panagiotou, Matthew Puc, Pedram Razavi, Elizabeth V. Robilotti, Miriam Santos-Dutra, Andrew L. Schmidt, Dimpy P. Shah, Sumit A. Shah, Kendra Vieira, Lisa B. Weissmann, Trisha M. Wise-Draper, Ulysses Wu, Julie Tsu Yu Wu, Toni K. Choueiri, Sanjay Mishra, Jeremy L. Warner, Benjamin French, Dimitrios Farmakiotis

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: The frequency of coinfections and their association with outcomes have not been adequately studied among patients with cancer and coronavirus disease 2019 (COVID-19), a high-risk group for coinfection. Methods: We included adult (≥18 years) patients with active or prior hematologic or invasive solid malignancies and laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection, using data from the COVID-19 and Cancer Consortium (CCC19, NCT04354701). We captured coinfections withinâ±2 weeks from diagnosis of COVID-19, identified factors cross-sectionally associated with risk of coinfection, and quantified the association of coinfections with 30-day mortality. Results: Among 8765 patients (hospitalized or not; median age, 65 years; 47.4% male), 16.6% developed coinfections: 12.1% bacterial, 2.1% viral, 0.9% fungal. An additional 6.4% only had clinical diagnosis of a coinfection. The adjusted risk of any coinfection was positively associated with age >50 years, male sex, cardiovascular, pulmonary, and renal comorbidities, diabetes, hematologic malignancy, multiple malignancies, Eastern Cooperative Oncology Group Performance Status, progressing cancer, recent cytotoxic chemotherapy, and baseline corticosteroids; the adjusted risk of superinfection was positively associated with tocilizumab administration. Among hospitalized patients, high neutrophil count and C-reactive protein were positively associated with bacterial coinfection risk, and high or low neutrophil count with fungal coinfection risk. Adjusted mortality rates were significantly higher among patients with bacterial (odds ratio [OR], 1.61; 95% CI, 1.33-1.95) and fungal (OR, 2.20; 95% CI, 1.28-3.76) coinfections. Conclusions: Viral and fungal coinfections are infrequent among patients with cancer and COVID-19, with the latter associated with very high mortality rates. Clinical and laboratory parameters can be used to guide early empiric antimicrobial therapy, which may improve clinical outcomes.

Original languageEnglish (US)
Article numberofac037
JournalOpen Forum Infectious Diseases
Issue number3
StatePublished - Mar 2022
Externally publishedYes


  • CAPA (COVID-19-Associated pulmonary aspergillosis)
  • COVID-19
  • bacterial infections
  • mucormycoses
  • viral infections

ASJC Scopus subject areas

  • Infectious Diseases
  • Oncology


Dive into the research topics of 'Coinfections in Patients with Cancer and COVID-19: A COVID-19 and Cancer Consortium (CCC19) Study'. Together they form a unique fingerprint.

Cite this