TY - JOUR
T1 - Cognitive impairment is correlated with reduced quality of life in patients with clinically isolated syndrome
AU - Anhoque, Carolina Fiorin
AU - Biccas-Neto, Laurentino
AU - Domingues, Simone Cristina A.
AU - Teixeira, Antônio Lúcio
AU - Domingues, Renan Barros
PY - 2013/2
Y1 - 2013/2
N2 - Objective: To evaluate the quality of life (QoL) and potential QoL determinants in patients with clinically isolated syndrome (CIS). Methods: Eighteen CIS patients and eighteen controls were submitted to QoL evaluation with Functional Assessment of Multiple Sclerosis QoL instrument (FAMS). Cognition was evaluated with specific battery tests; Anxiety and depression with Beck Anxiety (BAI) and Depression (BDI) Inventories and Neurological disability with Guy's Neurological Disability Scale (GNDS). Results: There was a significant difference in QoL between CIS patients and controls. CIS patients had worse performance in Paced Auditory Serial Addition 2 seconds (p=0.009) and fluency tests (p=0.0038). There was a significant difference in BAI (p=0.003), but no significant difference in BDI between patients and controls. There were significant correlations between QoL measure and verbal fluency and Stroop's test. Conclusions: Cognition, but not anxiety, depression and disability, was associated with reduced quality of life.
AB - Objective: To evaluate the quality of life (QoL) and potential QoL determinants in patients with clinically isolated syndrome (CIS). Methods: Eighteen CIS patients and eighteen controls were submitted to QoL evaluation with Functional Assessment of Multiple Sclerosis QoL instrument (FAMS). Cognition was evaluated with specific battery tests; Anxiety and depression with Beck Anxiety (BAI) and Depression (BDI) Inventories and Neurological disability with Guy's Neurological Disability Scale (GNDS). Results: There was a significant difference in QoL between CIS patients and controls. CIS patients had worse performance in Paced Auditory Serial Addition 2 seconds (p=0.009) and fluency tests (p=0.0038). There was a significant difference in BAI (p=0.003), but no significant difference in BDI between patients and controls. There were significant correlations between QoL measure and verbal fluency and Stroop's test. Conclusions: Cognition, but not anxiety, depression and disability, was associated with reduced quality of life.
KW - Anxiety
KW - Clinically isolated syndrome
KW - Cognition
KW - Depression
KW - Quality of life
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U2 - 10.1590/S0004-282X2013005000004
DO - 10.1590/S0004-282X2013005000004
M3 - Article
C2 - 23295369
AN - SCOPUS:84873684635
SN - 0004-282X
VL - 71
SP - 74
EP - 77
JO - Arquivos de neuro-psiquiatria
JF - Arquivos de neuro-psiquiatria
IS - 2
ER -