Cognitive impairment in patients with clinically isolated syndrome

Carolina Fiorin Anhoque, Laurentino Biccas Neto, Simone Cristina Aires Domingues, Antônio Lúcio Teixeira, Renan Barros Domingues

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). Objective: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. Methods: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. Results: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. Conclusion: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.

Original languageEnglish (US)
Pages (from-to)266-269
Number of pages4
JournalDementia e Neuropsychologia
Issue number4
StatePublished - 2012
Externally publishedYes


  • Clinically isolated syndrome
  • Cognition
  • Neuropsychological tests

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cognitive Neuroscience


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