Cognitive impairment in patients with clinically isolated syndrome

Carolina Fiorin Anhoque; Laurentino Biccas Neto; Simone Cristina Aires Domingues; Antônio Lúcio Teixeira; Renan Barros Domingues

doi:10.1590/S1980-57642012DN06040011

Cognitive impairment in patients with clinically isolated syndrome

Carolina Fiorin Anhoque, Laurentino Biccas Neto, Simone Cristina Aires Domingues, Antônio Lúcio Teixeira, Renan Barros Domingues

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). Objective: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. Methods: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. Results: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. Conclusion: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.

Original language	English (US)
Pages (from-to)	266-269
Number of pages	4
Journal	Dementia e Neuropsychologia
Volume	6
Issue number	4
DOIs	https://doi.org/10.1590/S1980-57642012DN06040011
State	Published - 2012
Externally published	Yes

Keywords

Clinically isolated syndrome
Cognition
Neuropsychological tests

ASJC Scopus subject areas

Sensory Systems
Neurology
Geriatrics and Gerontology
Clinical Neurology
Cognitive Neuroscience

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10.1590/S1980-57642012DN06040011

Cite this

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title = "Cognitive impairment in patients with clinically isolated syndrome",

abstract = "Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). Objective: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. Methods: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. Results: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. Conclusion: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.",

keywords = "Clinically isolated syndrome, Cognition, Neuropsychological tests",

author = "Anhoque, {Carolina Fiorin} and Neto, {Laurentino Biccas} and Domingues, {Simone Cristina Aires} and Teixeira, {Ant{\^o}nio L{\'u}cio} and Domingues, {Renan Barros}",

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T1 - Cognitive impairment in patients with clinically isolated syndrome

AU - Anhoque, Carolina Fiorin

AU - Neto, Laurentino Biccas

AU - Domingues, Simone Cristina Aires

AU - Teixeira, Antônio Lúcio

AU - Domingues, Renan Barros

PY - 2012

Y1 - 2012

N2 - Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). Objective: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. Methods: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. Results: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. Conclusion: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.

AB - Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). Objective: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. Methods: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. Results: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. Conclusion: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.

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Cognitive impairment in patients with clinically isolated syndrome

Abstract

Keywords

ASJC Scopus subject areas

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