Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 53-61 |
| Number of pages | 9 |
| Journal | Journal of Neuroimmunology |
| Volume | 221 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Apr 2010 |
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ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
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Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C. / Hilsabeck, Robin C.; Anstead, Gregory M; Webb, Amy L.; Hoyumpa, Anastasio; Ingmundson, Paul; Holliday, Steve; Zhang, Qiong; Casas, Angela M.; Jovel, Marci; Stern, Stephen L.
In: Journal of Neuroimmunology, Vol. 221, No. 1-2, 04.2010, p. 53-61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C
AU - Hilsabeck, Robin C.
AU - Anstead, Gregory M
AU - Webb, Amy L.
AU - Hoyumpa, Anastasio
AU - Ingmundson, Paul
AU - Holliday, Steve
AU - Zhang, Qiong
AU - Casas, Angela M.
AU - Jovel, Marci
AU - Stern, Stephen L.
PY - 2010/4
Y1 - 2010/4
N2 - The etiology of cognitive dysfunction in chronic hepatitis C (CHC) infection is unknown. Among the possibilities is cytokine activation, which has been associated with cognitive dysfunction in other chronic conditions. The purpose of this study was to investigate the relationship between endogenous IFN-α, IL-6, and TNF-α and cognitive functioning in CHC patients. Seventy-eight veterans with CHC underwent cognitive testing and measurement of serum cytokines. In patients with detectable IFN-α, higher levels of IL-6 and TNF-α were related to poorer cognitive functioning. Findings suggest CHC patients with immune responses characterized by elevated IFN-α may be at risk for cognitive difficulties.
AB - The etiology of cognitive dysfunction in chronic hepatitis C (CHC) infection is unknown. Among the possibilities is cytokine activation, which has been associated with cognitive dysfunction in other chronic conditions. The purpose of this study was to investigate the relationship between endogenous IFN-α, IL-6, and TNF-α and cognitive functioning in CHC patients. Seventy-eight veterans with CHC underwent cognitive testing and measurement of serum cytokines. In patients with detectable IFN-α, higher levels of IL-6 and TNF-α were related to poorer cognitive functioning. Findings suggest CHC patients with immune responses characterized by elevated IFN-α may be at risk for cognitive difficulties.
KW - ANAM
KW - Cognitive dysfunction
KW - Cytokines
KW - Hepatitis C
KW - Immune system
KW - Interferon-α
UR - http://www.scopus.com/inward/record.url?scp=77951234312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951234312&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2010.01.017
DO - 10.1016/j.jneuroim.2010.01.017
M3 - Article
C2 - 20181398
AN - SCOPUS:77951234312
VL - 221
SP - 53
EP - 61
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -