@article{c442c4baed1242889e2df394aa71d16d,
title = "Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C",
abstract = "The etiology of cognitive dysfunction in chronic hepatitis C (CHC) infection is unknown. Among the possibilities is cytokine activation, which has been associated with cognitive dysfunction in other chronic conditions. The purpose of this study was to investigate the relationship between endogenous IFN-α, IL-6, and TNF-α and cognitive functioning in CHC patients. Seventy-eight veterans with CHC underwent cognitive testing and measurement of serum cytokines. In patients with detectable IFN-α, higher levels of IL-6 and TNF-α were related to poorer cognitive functioning. Findings suggest CHC patients with immune responses characterized by elevated IFN-α may be at risk for cognitive difficulties.",
keywords = "ANAM, Cognitive dysfunction, Cytokines, Hepatitis C, Immune system, Interferon-α",
author = "Hilsabeck, {Robin C.} and Anstead, {Gregory M.} and Webb, {Amy L.} and Anastasio Hoyumpa and Paul Ingmundson and Steve Holliday and Qiong Zhang and Casas, {Angela M.} and Marci Jovel and Stern, {Stephen L.}",
note = "Funding Information: This material is the result of work supported with resources and the use of facilities at the South Texas Veterans Health Care System and University of Texas Health Sciences Center at San Antonio. The work was supported by grants from VISN-17 of the Veterans Health Administration to SLS and National Institutes of Health ( K23 NS051244 ) to RCH. In addition, this project was supported by Award Numbers UL 1RR025767 and M01-RR-01346 from the National Center for Research Resources . The content is solely the responsibility of the authors and does not necessarily represent the official views of the Veterans Health Administration or the National Institutes of Health.",
year = "2010",
month = apr,
doi = "10.1016/j.jneuroim.2010.01.017",
language = "English (US)",
volume = "221",
pages = "53--61",
journal = "Advances in Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",
}