Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C

Robin C. Hilsabeck; Gregory M. Anstead; Amy L. Webb; Anastasio Hoyumpa; Paul Ingmundson; Steve Holliday; Qiong Zhang; Angela M. Casas; Marci Jovel; Stephen L. Stern

doi:10.1016/j.jneuroim.2010.01.017

Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C

Robin C. Hilsabeck, Gregory M. Anstead, Amy L. Webb, Anastasio Hoyumpa, Paul Ingmundson, Steve Holliday, Qiong Zhang, Angela M. Casas, Marci Jovel, Stephen L. Stern

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The etiology of cognitive dysfunction in chronic hepatitis C (CHC) infection is unknown. Among the possibilities is cytokine activation, which has been associated with cognitive dysfunction in other chronic conditions. The purpose of this study was to investigate the relationship between endogenous IFN-α, IL-6, and TNF-α and cognitive functioning in CHC patients. Seventy-eight veterans with CHC underwent cognitive testing and measurement of serum cytokines. In patients with detectable IFN-α, higher levels of IL-6 and TNF-α were related to poorer cognitive functioning. Findings suggest CHC patients with immune responses characterized by elevated IFN-α may be at risk for cognitive difficulties.

Original language	English (US)
Pages (from-to)	53-61
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	221
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.01.017
State	Published - Apr 1 2010

Keywords

ANAM
Cognitive dysfunction
Cytokines
Hepatitis C
Immune system
Interferon-α

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Cognitive efficiency is associated with endogenous cytokine levels in patients with chronic hepatitis C. / Hilsabeck, Robin C.; Anstead, Gregory M.; Webb, Amy L.; Hoyumpa, Anastasio; Ingmundson, Paul; Holliday, Steve; Zhang, Qiong; Casas, Angela M.; Jovel, Marci; Stern, Stephen L.

In: Journal of Neuroimmunology, Vol. 221, No. 1-2, 01.04.2010, p. 53-61.

Research output: Contribution to journal › Article › peer-review

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abstract = "The etiology of cognitive dysfunction in chronic hepatitis C (CHC) infection is unknown. Among the possibilities is cytokine activation, which has been associated with cognitive dysfunction in other chronic conditions. The purpose of this study was to investigate the relationship between endogenous IFN-α, IL-6, and TNF-α and cognitive functioning in CHC patients. Seventy-eight veterans with CHC underwent cognitive testing and measurement of serum cytokines. In patients with detectable IFN-α, higher levels of IL-6 and TNF-α were related to poorer cognitive functioning. Findings suggest CHC patients with immune responses characterized by elevated IFN-α may be at risk for cognitive difficulties.",

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