Coccidioidomycosis: Recognizing the varied clinical presentations

Gregory M. Anstead, Jose Cadena-Zuluaga

Research output: Contribution to journalReview article

1 Scopus citations


Although coccidioidomycosis is often asymptomatic, it can have a variety of manifestations, including acute and chronic respiratory disease, osteoarticular destruction, and meningitis. The incidence of coccidioidomycosis is increasing as a result of travel and the influx of susceptible persons into the southwestern United States, where the fungal pathogens - Coccidioides immitis and Coccidioides posadasii - are endemic. Diagnostic methods include culture, serology, histopathological examination, and antigen detection, but all have limited sensitivity. Coccidioidomycosis can be successfully treated with azoles and amphotericin B; however, a prolonged duration of treatment may be required, relapse is common, and permanent disability and death may occur.

Original languageEnglish (US)
Pages (from-to)198-210
Number of pages13
JournalInfections in Medicine
Issue number7
Publication statusPublished - Jul 1 2009



  • Antifungal therapy
  • Coccidioides
  • Coccidioidomycosis
  • Endemic mycoses

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Anstead, G. M., & Cadena-Zuluaga, J. (2009). Coccidioidomycosis: Recognizing the varied clinical presentations. Infections in Medicine, 26(7), 198-210.