Coccidioidomycosis: Recent Updates

Meryl Twarog, George R. Thompson

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Coccidioidomycosis manifests as a variety of clinical manifestations and ranges in severity from asymptomatic exposure with resultant immunity to reinfection, to fulminant, and life-threatening disseminated disease. Primary coccidioidal pneumonia represents the most common clinical form of infection, and the incidence continues to increase. Within the endemic region, primary pulmonary coccidioidomycosis represents up to 29% of all community-acquired pneumonia emphasizing the frequency with which clinicians encounter this endemic mycosis. Chronic infection develops in 3 to 5% of patients, and almost all morbidity and mortality observed in coccidioidomycosis occur in these forms (e.g., chronic pulmonary disease, extrapulmonary manifestations). This review summarizes the ecology, epidemiology, manifestations of disease, and treatment options currently available for coccidioidomycosis.

Original languageEnglish (US)
Pages (from-to)746-755
Number of pages10
JournalSeminars in Respiratory and Critical Care Medicine
Volume36
Issue number5
DOIs
StatePublished - Oct 25 2015
Externally publishedYes

Keywords

  • Coccidioides
  • coccidioidomycosis
  • epidemiology
  • review
  • treatment
  • Valley Fever

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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