Cocaine's effect on plasma oxytocin concentrations in the baboon during late pregnancy

M. A. Morgan, M. B.O.M. Honnebier, C. Mecenas, P. W. Nathanielsz

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

OBJECTIVE: The hypothesis for this investigation was that intravenous cocaine would result in an elevation of maternal plasma oxytocin levels in the baboon during late pregnancy. STUDY DESIGN: Five gravid chronically instrumented baboons had timed arterial blood samples obtained before and after an intravenous bolus cocaine infusion at least 5 days after surgery. Plasma oxytocin concentrations were measured by specific radioimmunoassays, and baseline samples were compared with postcocaine samples. RESULTS: The plasma oxytocin concentrations were significantly elevated at all sampling times after the 1.0 mg/kg cocaine dose (p < 0.05). CONCLUSION: The increased oxytocin concentrations after cocaine use may be responsible for the increased incidence of preterm labor.

Original languageEnglish (US)
Pages (from-to)1026-1027
Number of pages2
JournalAmerican Journal of Obstetrics and Gynecology
Volume174
Issue number3
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Keywords

  • baboon
  • Cocaine
  • oxytocin
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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