Cocaine-Induced Coronary-Artery Constriction

John J. Ambre; R. Douglas Wilkerson; Theodore D. Fraker; Peter N. Temesy-Armos; Kensuke Egashira; James P. Morgan; Louis L. Cregler; Anthony E. Folev; Richard A Lange; Ricardo G. Cigarroa; L. David Hillis

doi:10.1056/NEJM199004263221714

Cocaine-Induced Coronary-Artery Constriction

John J. Ambre, R. Douglas Wilkerson, Theodore D. Fraker, Peter N. Temesy-Armos, Kensuke Egashira, James P. Morgan, Louis L. Cregler, Anthony E. Folev, Richard A Lange, Ricardo G. Cigarroa, L. David Hillis

Research output: Contribution to journal › Letter › peer-review

4 Scopus citations

Abstract

To the Editor: The conclusion of Lange et al. (Dec. 7 issue)¹ from their study of cocaine-induced coronary-artery constriction implies that they know the shape of the cocaine dose–response curve for cardiac effects. They used doses of 110 to 210 mg intranasally (which are only about 30 percent bioavailable²) and produced cocaine concentrations of 30 to 220 ng per milliliter. We have acquired noninvasive and clinical cardiac data in 30 studies of intravenous cocaine users at plasma cocaine concentrations in the range produced by recreational use. In addition to five subjects receiving 30 mg of cocaine by intravenous injection,.

Original language	English (US)
Pages (from-to)	1235-1237
Number of pages	3
Journal	New England Journal of Medicine
Volume	322
Issue number	17
DOIs	https://doi.org/10.1056/NEJM199004263221714
State	Published - Apr 26 1990
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJM199004263221714

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title = "Cocaine-Induced Coronary-Artery Constriction",

abstract = "To the Editor: The conclusion of Lange et al. (Dec. 7 issue)1 from their study of cocaine-induced coronary-artery constriction implies that they know the shape of the cocaine dose–response curve for cardiac effects. They used doses of 110 to 210 mg intranasally (which are only about 30 percent bioavailable2) and produced cocaine concentrations of 30 to 220 ng per milliliter. We have acquired noninvasive and clinical cardiac data in 30 studies of intravenous cocaine users at plasma cocaine concentrations in the range produced by recreational use. In addition to five subjects receiving 30 mg of cocaine by intravenous injection,.",

author = "Ambre, {John J.} and Wilkerson, {R. Douglas} and Fraker, {Theodore D.} and Temesy-Armos, {Peter N.} and Kensuke Egashira and Morgan, {James P.} and Cregler, {Louis L.} and Folev, {Anthony E.} and Lange, {Richard A} and Cigarroa, {Ricardo G.} and Hillis, {L. David}",

year = "1990",

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doi = "10.1056/NEJM199004263221714",

language = "English (US)",

volume = "322",

pages = "1235--1237",

journal = "New England Journal of Medicine",

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TY - JOUR

T1 - Cocaine-Induced Coronary-Artery Constriction

AU - Ambre, John J.

AU - Wilkerson, R. Douglas

AU - Fraker, Theodore D.

AU - Temesy-Armos, Peter N.

AU - Egashira, Kensuke

AU - Morgan, James P.

AU - Cregler, Louis L.

AU - Folev, Anthony E.

AU - Lange, Richard A

AU - Cigarroa, Ricardo G.

AU - Hillis, L. David

PY - 1990/4/26

Y1 - 1990/4/26

N2 - To the Editor: The conclusion of Lange et al. (Dec. 7 issue)1 from their study of cocaine-induced coronary-artery constriction implies that they know the shape of the cocaine dose–response curve for cardiac effects. They used doses of 110 to 210 mg intranasally (which are only about 30 percent bioavailable2) and produced cocaine concentrations of 30 to 220 ng per milliliter. We have acquired noninvasive and clinical cardiac data in 30 studies of intravenous cocaine users at plasma cocaine concentrations in the range produced by recreational use. In addition to five subjects receiving 30 mg of cocaine by intravenous injection,.

AB - To the Editor: The conclusion of Lange et al. (Dec. 7 issue)1 from their study of cocaine-induced coronary-artery constriction implies that they know the shape of the cocaine dose–response curve for cardiac effects. They used doses of 110 to 210 mg intranasally (which are only about 30 percent bioavailable2) and produced cocaine concentrations of 30 to 220 ng per milliliter. We have acquired noninvasive and clinical cardiac data in 30 studies of intravenous cocaine users at plasma cocaine concentrations in the range produced by recreational use. In addition to five subjects receiving 30 mg of cocaine by intravenous injection,.

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Cocaine-Induced Coronary-Artery Constriction

Abstract

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