The effects of cocaine on the maternal and fetal pituitary-adrenal axis in vivo during pregnancy have not been reported. Six pregnant ewes and their fetuses underwent instrumentation at 113 to 119 days' gestation. Ewes were assigned to receive an intravenous bolus injection of vehicle or cocaine (0.5, 1.0, or 2.0 mg · kg–1) at 124 to 136 days' gestation. Maternal arterial blood gases, fetal pH and fetal Pco2 were unchanged after injection of cocaine or vehicle. After administration of 2.0 mg · kg–1 cocaine, arterial fetal Po2 fell 3.2 ± 1.72 mm Hg (p < 0.05) at + 5 minutes, returning to baseline by +15 minutes. Maternal and fetal adrenocorticotropin levels rose within 5 minutes after the highest cocaine dose (p < 0.05). There was a significant (p < 0.05) increase in maternal Cortisol at all doses of cocaine and in fetal Cortisol at +15 minutes after the 2.0 mg · kg−1.
ASJC Scopus subject areas
- Obstetrics and Gynecology