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Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells
Yannan Jia
, Lina Han
, Cassandra L. Ramage
, Zhe Wang
, Connie C. Weng
, Lei Yang
, Simona Colla
, Helen Ma
, Weiguo Zhang
, Michael Andreeff
, Naval Daver
, Nitin Jain
, Naveen Pemmaraju
, Kapil Bhalla
, Satu Mustjoki
, Peiyi Zhang
, Guangrong Zheng
,
Daohong Zhou
, Qi Zhang
, Marina Konopleva
Department of Biochemistry & Structural Biology
Greehey Children's Cancer Research Institute
Mays Cancer Center
Research output
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Contribution to journal
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Article
›
peer-review
45
Scopus citations
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Medicine and Dentistry
Chemotherapy
100%
Protein Degradation
100%
Leukemia Cell
100%
Chimera
100%
Cells
100%
Acute Myeloid Leukemia
75%
Combination Therapy
50%
Cellular Senescence
50%
Platelet
50%
Protein
25%
Xenograft
25%
Toxicity
25%
Malignant Neoplasm
25%
Drug Resistance
25%
Leukemia
25%
Cell Viability
25%
Antiapoptotic
25%
Ubiquitination
25%
Ligase
25%
Patient
25%
Hematopoietic Cell Line
25%
Pharmacology, Toxicology and Pharmaceutical Science
Leukemia
100%
Acute Myeloid Leukemia
75%
Protein
25%
Toxicity
25%
Malignant Neoplasm
25%
Ligase
25%
Navitoclax
25%
Cell Viability
25%