Cloning the gene encoding Schistosoma mansoni p50, an immunophilin

David Kiang, Amr M. Karim, Philip T. LoVerde

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A 2.2-kb fragment of genomic DNA encoding Schistosoma mansoni immunophilin p50 (Smp50) was identified on a 14-kb genomic clone. The sequence of Smp50 reveals seven exons interrupted by six small introns ranging from 28-35 bp in size. The transcription start point, defined by primer extension analysis of schistosome RNA, begins at 30 bp upstream from the start AUG codon. Smp50 lacks a TATA box and appears to be a single-copy gene.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalGene
Volume170
Issue number1
DOIs
StatePublished - Apr 17 1996

Keywords

  • FK506-binding protein
  • p59 protein family

ASJC Scopus subject areas

  • Genetics

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