Abstract
A cDNA encoding the nucleic acid-binding domain of the hnRNP C-type protein has been cloned by DNA-affinity screening of pituitary-derived expression libraries. An analysis revealed sequence identity with the human C-type cDNA and demonstrated the presence of a peptide sequence contained within the single-stranded DNA-binding protein, UP2, which was absent from the human cDNA. Structural analysis of the protein encoded by the rat cDNA demonstrated a net charge of + 15 with 14.56% and 6.33% lysines and arginines, respectively, and an amino acid sequence that is consistent with an extensive helix-loop-helix-turn-helix structure.
Original language | English (US) |
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Pages (from-to) | 306-309 |
Number of pages | 4 |
Journal | BBA - Gene Structure and Expression |
Volume | 1048 |
Issue number | 2-3 |
DOIs | |
State | Published - Apr 6 1990 |
Keywords
- (Rat)
- C protein
- DNA-binding
- Helix-loop-helix
- Helix-turn-helix
- HnRNP
ASJC Scopus subject areas
- Structural Biology
- Biophysics
- Biochemistry
- Genetics