Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells

Robert Hromas, Hal E. Broxmeyer, Chang Kim, Harikrishna Nakshatri, Kent Christopherson, Mohd Azam, Yong Hao Hou

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

Chemokines are a family of related proteins that regulate leukocyte infiltration into inflamed tissue and play important roles in many disease processes. Chemokines are divided into two major groups, CC or CXC, based on their sequence around the amino terminal cysteines. We report the PCR cloning of a novel human chemokine termed BRAK for its initial isolation from breast and kidney cells. This novel chemokine is distantly related to other CXC chemokines (30% identity with MIP-2α and β) and shares several biological activities. BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31.

Original languageEnglish (US)
Pages (from-to)703-706
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume255
Issue number3
DOIs
StatePublished - Feb 24 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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