TY - JOUR
T1 - Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells
AU - Hromas, Robert
AU - Broxmeyer, Hal E.
AU - Kim, Chang
AU - Nakshatri, Harikrishna
AU - Christopherson, Kent
AU - Azam, Mohd
AU - Hou, Yong Hao
PY - 1999/2/24
Y1 - 1999/2/24
N2 - Chemokines are a family of related proteins that regulate leukocyte infiltration into inflamed tissue and play important roles in many disease processes. Chemokines are divided into two major groups, CC or CXC, based on their sequence around the amino terminal cysteines. We report the PCR cloning of a novel human chemokine termed BRAK for its initial isolation from breast and kidney cells. This novel chemokine is distantly related to other CXC chemokines (30% identity with MIP-2α and β) and shares several biological activities. BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31.
AB - Chemokines are a family of related proteins that regulate leukocyte infiltration into inflamed tissue and play important roles in many disease processes. Chemokines are divided into two major groups, CC or CXC, based on their sequence around the amino terminal cysteines. We report the PCR cloning of a novel human chemokine termed BRAK for its initial isolation from breast and kidney cells. This novel chemokine is distantly related to other CXC chemokines (30% identity with MIP-2α and β) and shares several biological activities. BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31.
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U2 - 10.1006/bbrc.1999.0257
DO - 10.1006/bbrc.1999.0257
M3 - Article
C2 - 10049774
AN - SCOPUS:0033599317
SN - 0006-291X
VL - 255
SP - 703
EP - 706
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -