Cloning and expression of a receptor for an insecticidal toxin of Bacillus thuringiensis

R. K. Vadlamudi, E. Weber, I. Ji, T. H. Ji, L. A. Bulla

Research output: Contribution to journalArticlepeer-review

276 Scopus citations


Environmentally friendly toxins of Bacillus thuringiensis are effective in controlling agriculturally and biomedically harmful insects. However, little is known about the insect receptor molecules that bind these toxins and the mechanism of insecticidal activity. We report here for the first time the cloning and expression of a cDNA that encodes a receptor (BT-R1) of the tobacco hornworm Manduca sexta for an insecticidal toxin of B. thuringiensis. The receptor is a 210-kDa membrane glycoprotein that specifically binds the cryIA(b) toxin of B. thuringiensis subsp. berliner and leads to death of the hornworm. BT-R1 shares sequence similarity with the cadherin superfamily of proteins.

Original languageEnglish (US)
Pages (from-to)5490-5494
Number of pages5
JournalJournal of Biological Chemistry
Issue number10
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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