Cloned hepatitis delta virus cDNA is infectious in the chimpanzee

C. Sureau, J. Taylor, M. Chao, J. W. Eichberg, R. E. Lanford

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A head-to-tail trimer of a full-length cDNA clone of the hepatitis delta virus (HDV) genome was examined for infectivity by direct inoculation into the liver of a chimpanzee that was already infected with hepatitis B virus. Five weeks after inoculation, a marked elevation of serum alanine aminotransferase activity was observed, followed by the appearance of high levels of HDV RNA and antigen in both liver and serum and a high level of viral particles in the serum. A transient suppression of hepatitis B virus replication was evident during the acute phase of HDV infection. Seroconversion for antibodies to delta antigen occurred 3 weeks after the onset of the disease. These results demonstrate that a typical HDV infection can be initiated by inoculation of a susceptible animal with recombinant HDV cDNA.

Original languageEnglish (US)
Pages (from-to)4292-4297
Number of pages6
JournalJournal of Virology
Volume63
Issue number10
StatePublished - 1989
Externally publishedYes

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Hepatitis delta virus
Hepatitis Delta Virus
Pan troglodytes
Complementary DNA
Hepatitis delta Antigens
Hepatitis D
Hepatitis B virus
Virus Diseases
Serum
antigens
liver
Liver
seroconversion
Virus Replication
virus replication
Alanine Transaminase
alanine transaminase
virion
infection
Virion

ASJC Scopus subject areas

  • Immunology

Cite this

Sureau, C., Taylor, J., Chao, M., Eichberg, J. W., & Lanford, R. E. (1989). Cloned hepatitis delta virus cDNA is infectious in the chimpanzee. Journal of Virology, 63(10), 4292-4297.

Cloned hepatitis delta virus cDNA is infectious in the chimpanzee. / Sureau, C.; Taylor, J.; Chao, M.; Eichberg, J. W.; Lanford, R. E.

In: Journal of Virology, Vol. 63, No. 10, 1989, p. 4292-4297.

Research output: Contribution to journalArticle

Sureau, C, Taylor, J, Chao, M, Eichberg, JW & Lanford, RE 1989, 'Cloned hepatitis delta virus cDNA is infectious in the chimpanzee', Journal of Virology, vol. 63, no. 10, pp. 4292-4297.
Sureau C, Taylor J, Chao M, Eichberg JW, Lanford RE. Cloned hepatitis delta virus cDNA is infectious in the chimpanzee. Journal of Virology. 1989;63(10):4292-4297.
Sureau, C. ; Taylor, J. ; Chao, M. ; Eichberg, J. W. ; Lanford, R. E. / Cloned hepatitis delta virus cDNA is infectious in the chimpanzee. In: Journal of Virology. 1989 ; Vol. 63, No. 10. pp. 4292-4297.
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