Cloned hepatitis delta virus cDNA is infectious in the chimpanzee

C. Sureau, J. Taylor, M. Chao, J. W. Eichberg, R. E. Lanford

    Research output: Contribution to journalArticlepeer-review

    41 Scopus citations

    Abstract

    A head-to-tail trimer of a full-length cDNA clone of the hepatitis delta virus (HDV) genome was examined for infectivity by direct inoculation into the liver of a chimpanzee that was already infected with hepatitis B virus. Five weeks after inoculation, a marked elevation of serum alanine aminotransferase activity was observed, followed by the appearance of high levels of HDV RNA and antigen in both liver and serum and a high level of viral particles in the serum. A transient suppression of hepatitis B virus replication was evident during the acute phase of HDV infection. Seroconversion for antibodies to delta antigen occurred 3 weeks after the onset of the disease. These results demonstrate that a typical HDV infection can be initiated by inoculation of a susceptible animal with recombinant HDV cDNA.

    Original languageEnglish (US)
    Pages (from-to)4292-4297
    Number of pages6
    JournalJournal of virology
    Volume63
    Issue number10
    DOIs
    StatePublished - 1989

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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