Clodronate. A randomized study in the treatment of cancer-related hypercalcemia

R. S. Witte, J. Koeller, T. E. Davis, A. B. Benson, B. G. Durie, A. Lipton, J. L. Stock, D. L. Citrin, T. P. Jacobs

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    27 Scopus citations


    Malignancy-associated hypercalcemia is a common and recalcitrant problem. Current modes of therapy are often ineffective or prohibitively toxic. Clodronate disodium is a diphosphonate capable of inhibiting bone resorption resulting in a hypocalcemic effect. In this randomized, placebo-controlled study, we investigated the effect of hydration only (Rx-1) vs the effect of hydration plus either intravenously administered clodronate disodium, 4 mg/kg of body weight per day for three days (Rx-2) or intravenously administered clodronate disodium, 12 mg/kg of body weight given once only (Rx-3). By the third day of observation, Rx-2 produced a significant 2.8 mg/dL (0.70 mmol/L) reduction in serum calcium levels, whereas Rx-1 and Rx-3 did not produce a significant hypocalcemic effect when compared with baseline values. There were no toxicities observed. Intravenously administered clodronate appears to be an excellent agent for the acute treatment of malignancy-associated hypercalcemia.

    Original languageEnglish (US)
    Pages (from-to)937-939
    Number of pages3
    JournalArchives of Internal Medicine
    Issue number5
    StatePublished - Aug 3 1987

    ASJC Scopus subject areas

    • Internal Medicine


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