Clinicopathological, Microbiological and Polymerase Chain Reaction Study in a Case of Nocardia Scleritis

Mamta Agarwal, Gazal Patnaik, Kaushal Sanghvi, A. R. Anand, M. K. Janani, Jyotirmay Biswas

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: To describe the clinicopathological, microbiological and polymerase chain reaction (PCR) study in a case of Nocardia scleritis. Methods: A retrospective chart review. Results: A 32-year old male presented with pain, redness and nodular scleral swelling in the left eye for the past two and a half months following an accidental rice powder injury. He was earlier diagnosed to have tubercular scleritis and treated with oral steroids and anti-tubercular therapy. A repeat scleral biopsy on histopathological examination showed granulomatous inflammation. Microbiological investigations revealed the growth of Gram +ve branching filamentous bacilli in culture suggestive of Nocardia sp. PCR based DNA sequencing identified the bacterium as Nocardia cyriacigeorgica. The patient responded to topical fortified amikacin (2.5%), fortified cefuroxime, oral sulfamethoxazole and trimethoprim with complete healing of scleritis. Conclusions: Nocardia scleritis can be a diagnostic challenge for clinicians. Newer molecular techniques along with histopathological and microbiological investigations can clinch the diagnosis.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalOcular Immunology and Inflammation
StatePublished - 2020
Externally publishedYes


  • Histopathology
  • Mycobacterium tuberculosis
  • nocardia
  • polymerase chain reaction
  • scleritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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