Clinicopathological and 123I-FP-CIT SPECT correlations in patients with dementia

Youngsin Jung, Lennon G. Jordan, Val J. Lowe, Kejal Kantarci, Joseph E. Parisi, Dennis W. Dickson, Melissa E. Murray, Ross R. Reichard, Tanis J. Ferman, David T. Jones, Jonathan Graff-Radford, Rodolfo Savica, Mary M. Machulda, Julie A. Fields, Laura A. Allen, Daniel A. Drubach, Erik K. St. Louis, Michael H. Silber, Clifford R. Jack, David S. KnopmanRonald C. Petersen, Bradley F. Boeve

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The relationship between clinicopathologic diagnosis and 123I-FP-CIT SPECT in 18 patients with dementia (12 with Lewy body disease) from one center in the United States was assessed. The sensitivity and specificity of abnormal 123I-FP-CIT SPECT with reduced striatal uptake on visual inspection for predicting Lewy body disease were 91.7% and 83.3%, respectively. The mean calculated putamen to occipital ratio (mPOR) based on regions of interest was significantly reduced in Lewy body disease compared to non-Lewy body disease cases (P = 0.002). In this study, abnormal 123I-FP-CIT SPECT was strongly associated with underlying Lewy body disease pathology, supporting the utility of 123I-FP-CIT SPECT in the clinical diagnosis of dementia with Lewy bodies.

Original languageEnglish (US)
Pages (from-to)376-381
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Volume5
Issue number3
DOIs
StatePublished - Mar 2018
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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    Jung, Y., Jordan, L. G., Lowe, V. J., Kantarci, K., Parisi, J. E., Dickson, D. W., Murray, M. E., Reichard, R. R., Ferman, T. J., Jones, D. T., Graff-Radford, J., Savica, R., Machulda, M. M., Fields, J. A., Allen, L. A., Drubach, D. A., St. Louis, E. K., Silber, M. H., Jack, C. R., ... Boeve, B. F. (2018). Clinicopathological and 123I-FP-CIT SPECT correlations in patients with dementia. Annals of Clinical and Translational Neurology, 5(3), 376-381. https://doi.org/10.1002/acn3.521