Clinical risk scores are sufficient to define primary prevention treatment strategies among asymptomatic patients

Charlotte Andersson, Ramachandran S. Vasan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Adequate screening for identifying individuals at risk of developing cardiovascular disease (CVD) is important because vascular disorders are a preventable cause of morbidity and mortality worldwide. Furthermore, the lifetime risk of developing CVD is high (an estimated 66% for men and >50% for women), and often the first symptom of disease is a sudden death, thereby occurring without an opportunity for intervention.1-3 Conventional risk factors aggregated as risk scores (such as the National Heart, Lung, and Blood Institute report on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel III, based on the Framingham risk score]) have shown to predict the 10-year risk of developing coronary heart disease (CHD) in most individuals,4,5 and the predictive capability of these risk factors extends during a 30-year time horizon.6 However, established risk scores may underestimate CVD risk in some individuals.7 In addition, it is also recognized now that even among those with an optimal risk factor profile at 55 years of age, the residual lifetime risk of CVD remains substantial (40% in men and 30% in women).3 These observations have motivated the search for additional risk factors (including imaging tests that detect subclinical atherosclerosis) that can enhance the predictive use of conventional risk factors.

Original languageEnglish (US)
Pages (from-to)390-397
Number of pages8
JournalCirculation: Cardiovascular Imaging
Issue number2
StatePublished - Mar 2014
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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