Clinical Relevance of Pharmacogenetics in Serotonin Syndrome

Dehuti Pandya, My Tran, Monica Verduzco-Gutierrez

Research output: Contribution to journalArticlepeer-review

Abstract

Serotonin syndrome is a predictable life-threatening condition that is caused by serotonergic stimulation of the central and peripheral nervous systems. A patient's genetic profile can amplify exposure risk as many serotonergic drugs are metabolized by CYP450 enzymes, and these enzymes may be altered in functionality. We report a case of an elderly man who presented with serotonin syndrome after a dose change in valproic acid 5 weeks prior. His medication list consisted of low-dose serotonergic agents, which is unusual as most cases of serotonin syndrome involve higher doses. A review of his pharmacogenetic profile is presented to retrospectively evaluate the additive risk for serotonin syndrome and implications on resuming serotonergic agents.

Original languageEnglish (US)
Article number8860434
JournalCase Reports in Psychiatry
Volume2020
DOIs
StatePublished - 2020

ASJC Scopus subject areas

  • Psychiatry and Mental health

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